Introduction/Background The aim of this study is to compare and investigate the histological outcomes between premenopausal and post-menopausal women with report of cervical cytological abnormality.

Methodology From January 2010 to May 2018, patients with abnormal cervical cytology followed by histopathologic examination were collected from Department of Obstetrics and Gynecology of Haeundae Paik Hospital. The patients were divided into two groups according to menopause status and the histologic results. This study included the following cervical cytological abnormalities: atypical squamous cells of undetermined significance (ASC-US), cannot exclude high-grade squamous intraepithelial lesion (ASC-H), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial leision (HSIL).

Results The results of the cervical cytology among the 438 premenopausal women were ASC-US (n=91), LSIL (n=90), HSIL (n=193) and ASC-H (n=64). The results were ASC-US (n=12), LSIL (n=21), HSIL (n=63) and ASC-H (n=19) in 115 postmenopausal women. According to cytology results, we divide into two groups, ASC-US and LSIL were classified as low risk group, ASC-H and HSIL as high risk group. Within the low risk cytology group, HSIL was 73.5% (133/181) by histologic biopsy in premenopausal women and 42.4% (14/33) in postmenopausal women. In high risk group, HSIL was 88.7% (228/257) in premenopausal group and 70.7% (58/82) in postmenopausal group. In both comparisons, there was a statistically significant difference between premenopausal and postmenopausal women.

Conclusion In conclusion, our comparative study’s finding showed significant difference in correlation of cytology and histology results from premenopausal group and postmenopausal group with cervical cytology abnormality. On the basis of this result, we think that since cytological results in postmenopausal women than premenopausal women have low sensitivity, follow up pap smear with high risk HPV testing would be a more conservative management and appropriate than immediate colposcopic biopsy.

Disclosure Nothing to disclose.