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EP718 Uterine tumour resembling ovarian sex cord tumour (UTROSCT): a case report
  1. E Karopoulou1,
  2. E Arkoumani2,
  3. A Arapaki1,
  4. K Strataki1,
  5. S Polykalas1,
  6. N Arnogiannaki2 and
  7. D Papatheodorou1
  1. 1Department of Gynecology
  2. 2Department of Pathology, ‘Agios Savvas’ General Anti-Cancer Hospital, Athens, Greece


Introduction/Background Uterine tumours with histologic resemblances to ovarian sex cord tumours are very rare neoplasms. The histogenesis of these distinctive lesions is unclear as well as their malignant potential. UTROSCT usually occurs in middle-aged women. Abnormal uterine bleeding and/or abdominal pain are the most common symptoms usually accompanying an enlarged uterus. There are no typical imaging findings and the diagnosis relies exclusively on histopathologic examination.

Methodology We report a case of a 47 year-old patient who was referred to the gynecologic department due to abnormal uterine bleeding. An endometrial curettage was performed. Histological examination revealed a neoplasm with characteristics of UTROSCT. A total abdominal hysterectomy with bilateral adnexectomy was performed. Under the microscope, the neoplasm found in the uterine cavity consisted of small-medium cells with light cytoplasm and small nuclei arranged in solid nests, trabeculae and ribbons. Mitotic activity was 1 mitosis per 10 HPF and necrosis was absent. On immunohistochemistry, tumor cells were positive for epithelial marker CKAE1/3, smooth muscle markers SMA and desmin and sex cord markers calretinin,CD99 and Melan-A. Staining for h-caldesmon, CD10 WT-1 and inhibin was negative and Ki67 was positive in about 5% of tumor cells.

Results The morphological and immunohistochemical characteristics of the cells set the diagnosis of UTROSCT. The patient is now without evidence of recurrence disease, 4 months after resection.

Conclusion Generally, these tumors are considered to be benign and tumors of low malignant potential but can easily relapse after incomplete resection. Hysterectomy with bilateral salpingo-oophorectomy should be performed in cases where fertility spearing is not required.

Disclosure Nothing to disclose.

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