Introduction/Background Gynecological lymphomas are uncommon and ovary is the most affected site. Their symptoms are similar to non-hematological tumors. Surgical treatments are not suitable for lymphomas, they demand chemotherapy, making etiological differentiation crucial.

We report three cases of B-cell lymphoma from gynecological tract: two cases in ovary and another in cervix.

Methodology Case 1: VS 38-yo, with complaint 1 of menorrhagia. Colposcopy, CT and USG showed an expansive lesion in uterine cervix and with invasion of the posterior bladder wall, pelvic lymphadenopathy. The biopsy showed proliferation of atypical large cells and the diagnosis of Diffuse large B cells lymphoma was concluded.

Case 2: TNM 29-yo, HIV+, with fever and weight loss. Ultrassound scan showed bilateral vascular solid-cystic adnexal masses. She underwent to bilateral salpingo-oophorectomy and biopsy of the peritoneal implants. The pathology reports reveals extensive infiltration by Burkitt’s lymphoma.

Case 3: CGM 32-yo, history of coughing and weight loss. CT showed a large mediastinal tumor and biopsy reveals High grade B cells lymphoma, double expressor Bcl6 (+) and C-myc (+). She underwent to chemotherapy (Hyper-CVAD).

Further investigation with PET-CT showed a solid-cystic ovary mass, suspected to be the primary site of the process (confirmed by bilateral salpingo-oophorectomy).

Results Case 1: VS was submitted to chemotherapy (R-CHOP) and hysterectomy. Remission in 12 months of follow-up.

Case 2: TNM underwent chemotherapy (H-CVAD) and radiotherapy. In remission after 9 months of treatment.

Case 3: CGM, after 11 months of diagnosis, she presented CNS infiltration.

Chemotherapy, follow by bone marrow transplant is expected.

Conclusion The cases illustrate the importance of correct diagnosis of primary gynecological lymphomas for proper chemotherapy and surgical treatment.

Disclosure Nothing to disclose.