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EP678 Pregnancy and postpartum changes in uterine cervical biopsy abnormalities at our hospital
  1. A Miura,
  2. N Yoshioka,
  3. S Kuji,
  4. I Deura,
  5. T Ohara,
  6. J Hasegawa and
  7. N Suzuki
  1. St. Marianna University School of Medicine, Kawasaki, Japan


Introduction/Background In general, abnormal uterine cervical cytology is found in the first trimester, we evaluate the colposcopy, and perform a cervical biopsy if needed likewise in non-pregnancy. As a result, if the case is diagnosed to be cervical intraepithelial neoplasia (CIN), the risk of progression to invasive cancer during pregnancy is low and some cases of regression after delivery have been reported. In this study, we examined the transition of abnormal cervical biopsy from pregnancy to postpartum.

Methodology We retrospectively examined the transition in histology during pregnancy and postpartum of 44 pregnant women who visited our oncology outpatient clinic from January 2014 to December 2018, including 27 cases of CIN1,6 cases of CIN2, 11 cases CIN3. Their mode of delivery includes 32 cases of vaginal delivery, 9 cases of cesarean section, 3 cases of unknown delivery style.

Results The diagnosis of cervical biopsy abnormalities was 22 cases before pregnancy and early pregnancy respectively. At the transition change of cervical tissue diagnosis from early pregnancy to postpartum, 19 (73%) cases of CIN1 were improved and 7 cases (27%) were unchanged. There were no cases treated during pregnancy. 5 cases underwent cervical conjunctivectomy after delivery, and a radical hysterectomy was performed on 1 case who had progressed of the medical condition.

Conclusion We found that the rate of regression of cervical tissue biopsy abnormalities in pregnant women decreased in the order of CIN1, CIN2 and CIN3, however, it is often relieved when giving birth. We assume that accurate diagnosis during early pregnancy is important because cervical cell collection and colposcopy get difficult as the gestational age goes further. In addition, cervical cytology was shown to be an important screen, because the diagnosis was often triggered by cervical cytology in early pregnan.

Disclosure Nothing to disclose.

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