Introduction/Background Preoperative risk stratification in endometrial cancer (EC) is mainly based on the histological diagnosis of endometrial biopsies. Yet, easily accessible clinical biomarkers sampled prior to surgery, might contribute to improved risk stratification. Previous studies demonstrated the prognostic value of haematological parameters. Cancer antigen 125 (CA-125) has been widely accepted as tumour marker in EC, yet so far not studied in relation to pre-operative haematological parameters. Our aim is to investigate the prognostic value of preoperative haematological parameters in relation with CA-125.
Methodology Data collection was performed out of available samples of the prospective multicentre PIPENDO cohort. A total of 285 patients (66%) had complete available serum analysis of at least one. Anaemia (<12 g/Dl), thrombocytosis (>390 × 109platelets/L), leucocytosis (>10 × 109/L) were related to CA-125 (>35 kU/L), patients, histopathological characteristics and outcome.
Results Preoperative anaemia was present in 9.8% (n=28), leucocytosis in 10.9% (n=31) and thrombocytosis in 7.4% (n=21). Anaemia, thrombocytosis and leucocytosis were associated with BMI, comorbidity of diabetes and hypertension. Age was only associated with anaemia. Histopathological characteristics showed no association between anaemia, thrombocytosis and leucocytosis.
In multivariate Cox regression analysis anaemia and increased CA-125 were associated as risk factor for recurrence with hazard ratio (HR) of 2.50 (95% CI, 1.20–5.24 p=0.016) and 2.02 (95% CI 1.10–3.71 p=0.024). Only increased CA-125 was associated as risk factor for overall survival with HR of 2.12 (95% CI 1.21–3.72 p=0.008).
Conclusion Preoperative anaemia and increased CA-125 are associated with a two times increased risk of recurrence in women with EC.
Disclosure Nothing to disclose.
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