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EP647 The effect of bariatric surgery on endometrial cancer
  1. D Vasileiadou1,2,
  2. K Antiochos2,
  3. M Litos1 and
  4. G Skrekas2
  1. 1Department of Obstetrics and Gynecology, Konstantopouleio General Hospital of Nea Ionia
  2. 2LapEndoSurgery: Advanced Laparoscopy and Bariatric Surgery, Athens, Greece


Introduction/Background It is well known that obesity is associated with an increased risk of cancer. Considering its high prevalence, obesity is an important risk factor for cancer. Obesity is not only associated with new cancer cases but also with more advanced cancer disease and increased cancer mortality. Moreover, several cancer types, such as endometrial and pancreatic cancer, are associated with type 2 diabetes, a common co-morbidity related to obesity. Endometrial cancer has the strongest association with obesity compared to all other cancers in women, the risk proportionally increasing as body mass index increases. Bariatric surgery is the most effective treatment for achieving weight loss and sustaining normal weight in patients with obesity.

Methodology The present study is a review of literature.

Results Bariatric surgery has been shown to reduce the overall cancer risk in patients with obesity. Regarding endometrial cancer, several large - scale studies and meta-analyses have shown significant reduction in the risk of endometrial cancer in women undergoing bariatric surgery, with an odds ratio of 0.317. The estimated risk reduction has been shown to be as high as 50–70%. Several studies have also reported regression of endometrial hyperplasia after bariatric surgery.

Conclusion Bariatric surgery may protect obese patients from endometrial cancer and may also benefit patients who are already suffering from its precursors. Weight loss and bariatric surgery may be suggested to patients as an adjunct to their treatment.

Disclosure Nothing to disclose.

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