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EP646 Could the long-term oncological safety of laparoscopic surgery in low risk endometrial cancer be also valid for the high intermediate and high-risk patients? A multi-center turkish gynecologic oncology group study conducted with 2745 endometrial cancer cases
  1. MA Vardar1,
  2. AB Guzel1,
  3. S Taşkın2,
  4. M Güngör2,
  5. N Özgül3,
  6. C Salman3,
  7. Ü Küçükgöz Güleç1,
  8. G Khatib1,
  9. İ Dünder2,
  10. F Ortaç2,
  11. K Yuce3,
  12. C Terek4,
  13. T Şimşek5,
  14. A Özsaran4,
  15. Ç Taşkıran6,
  16. A Onan7,
  17. G Çoban8,
  18. S Topuz9,
  19. F Demirkıran10,
  20. Ö Takmaz11,
  21. MF Köse12,
  22. A Göçmen13,
  23. G Seydaoglu14,
  24. D Gümürdülü15,
  25. A Ayhan16,
  26. TRSGO
  1. 1Gynecologic Oncology, Çukurova University, Adana
  2. 2Ankara University
  3. 3Hacettepe University, Ankara
  4. 4Ege University, İzmir
  5. 5Akdeniz University, Antalya
  6. 6Koç University, İstanbul
  7. 7Gazi University, Ankara
  8. 8Başkent University, Adana
  9. 9İstanbul University
  10. 10İstanbul University Cerrahpaşa
  11. 11Akdeniz Universitycıbadem University
  12. 12Medipol University
  13. 13Umraniye Training and Research Hospital, İstanbul
  14. 14Biostatistics
  15. 15Pathology, Çukurova University, Adana
  16. 16Başkent University, Ankara, Turkey


Introduction/Background In this study we aimed to compare the long-term oncological outcomes of laparotomy (LT) and laparoscopic (LS) surgeries in endometrial cancer under the light of 2016 ESMO-ESGO-ESTRO risk classification system, focusing on the high intermediate and high-risk categories.

Methodology Using multicentric database, overall (OS) and disease-free survivals (DFS) of 2745 endometrial cancer cases were compared according the surgery route, laparotomy vs laparoscopy. A sub-analysis was performed considering the 2016 ESMO-ESGO-ESTRO risk classification for endometrial cancer. Thus, high intermediate and high-risk patients were grouped and a comparison was made between the groups.

Results Among the enrolled patients 1743 (63.5%) were operated by laparotomy and 1002 (36.5%) were operated with laparoscopy. The total number of high intermediate and high-risk endometrial cancer cases was 734 (45%) patients in the LT group and 307 (30.7%) patients in the LS group. OS and DFS were not statistically different when compared between LS and LT groups in terms of low, intermediate, high intermediate and high-risk endometrial cancer.

Conclusion Regardless of the endometrial cancer risk category, long-term oncologic outcomes of LS were found to be comparable to those treated classically with LT. Our results are encouraging for primarily considering laparoscopic surgery for high intermediate and high-risk endometrial cancer cases in order to minimize surgical morbidity, as adjuvant therapies will mostly be offered to this population. It should be strongly emphasized that this suggestion is limited to gynecological oncology centers with high laparoscopical experience.

Disclosure Nothing to disclose.

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