Introduction/Background Uterine carcinosarcoma (UCS), grade 3 endometrioid adenocarcinomas (G3 EAC) and type two adenocarcinomas (Type2 EAC) are considered as high-grade endometrial adonocarcinomas. The aim of this study was to compare the clinicopathologic features and survival of patients with UCS, G3 EAC, Type 2 EAC.

Methodology A total of 235 patients were included in this study. Of them, 62 cases had uterine HGEAC (group 1), 93 cases had Type2 EAC (group 2), and 80 had UCS (group 3). The groups were compared in terms of clinical and pathological characteristics including age, initial symptom, surgical approach, stage, myometrial invasion (MI), lymphovascular space invasion (LVSI), lymph node invasion, adjuvant therapy, and survival. The Kaplan-Meier analysis was used to compare the survival outcomes.

Results There were no statistically significant differences among the groups with regard to age, nulliparity, menopausal status, and the main initial symptom. Omentectomy was performed significantly more in group 2, but the rate of optimal cytoreduction was similar among the groups. All groups were similar in terms of stage, depth of myometrial invasion, LVSI and lymph node metastasis. Chemotherapy was the main adjuvant therapy for UCS and Type2 EAC while radiotherapy was the main adjuvant therapy for G3 EAC. There were no differences among the groups in terms of disease-free survival (DFS) (p=0.941) and overall survival (OS) (p=0.504).

Conclusion Although the survival difference among the groups can not be revealed, these patients have different clinical and pathological features and they should be considered as different groups.

Disclosure Nothing to disclose.