Introduction/Background World Health Organization had identified morbid obesity as patients with body mass index (BMI) more than 40 kg/m². Obesity is known as a risk factor for endometrial cancer due to the increase of the deposited estrogen. This study was conducted to evaluate the morbid obesity effect on overall survival of the endometrial cancer.

Methodology The last 10 years' records and pathological reports of the endometrial cancer cases who were operated and followed up in Çukurova University Gynecologic Oncology Center were reviewed, retrospectively. Data regarding BMI and overall survival was reported in 520 patients of them. These patients were included in this study and stratified into two groups according to their BMI, <40 and ≥40. Groups' clinic, pathologic features and overall survival rates were compared.

Results There was 146 cases in the morbid obese group and 374 patients in the non-morbid group (BMI <40). Mean age of the groups was 58.5 and 56.2, respectively. Mean follow-up time was 51.6 months. There was no difference between groups concerning endometrioid or non-endometrioid histology, grade, stage, lymph node involvement, myometrial invasion, lympho-vascular invasion, postoperative complications, postoperative hospitalization time, adjuvant treatments and recurrence status. Comorbidities were significantly higher in the morbid obese group. Albeit that, groups' clinical and pathological features were homogeneously distributed overall survival rates were significantly different (p=0.054). Five-year survival rate was 85.3% in the morbid obese group and 90.1% in the non-morbid group.

Conclusion Overall survival of the morbidly obese endometrial cancer patients is significantly lower from those with <40 kg/m² BMI. The most acceptable explanation of this result is the most frequent comorbidities in this special group, which could be simply altered by life style changes. Morbidly obese endometrial cancer patients should be encouraged for life style changes and consulted to the dietary and endocrinology specialists.

Disclosure Nothing to disclose.