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EP521 Treatment of peritoneal metastases from endometrial cancer with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, a systematic review of the literature
  1. A Fotiou1,
  2. N Blontzos2,
  3. E Giovannopoulou3,
  4. A Prodromidou2,
  5. G Vorgias1,
  6. J Spiliotis4 and
  7. C Iavazzo1
  1. 1Gynaecologic Department, Metaxa Cancer Hospital, Piraeus
  2. 2Department of Obstetrics and Gynaecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens
  3. 3Democritus University of Thrace, Medical School, Alexandroupoli
  4. 4Surgical Oncology and HIPEC Department, Athens Medical Centre, Athens, Greece


Introduction/Background Endometrial cancer is the most common cancer of the female reproductive tract in developed countries. Peritoneal metastases from endometrial cancer as advanced stage disease or as a recurrence is not rare. The aim of the present study was to evaluate the efficacy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal disease from endometrial cancer.

Methodology A systematic search of the literature for articles published up to February 2019 was performed. All studies that reported outcomes after cytoreduction and hyperthermic intraperitoneal therapy for peritoneal metastases in patients treated for endometrial cancer were independently evaluated by two authors and the discrepancies were resolved by team consensus.

Results A total of 6 studies were eligible for our review and were included in the present study. 63 patients were recruited by these studies. 11 patients were treated primary with debulking surgery and hyperthermic intraperitoneal chemotherapy while 52 patients underwent this procedure for recurrent disease after their primary treatment. Histologic type, FIGO staging, peritoneal carcinomatosis index, cytoreduction completeness, adjuvant treatment and mean follow up period were documented. Of 63 patients 21 (33.3%) were reported to be disease free at the time of study publication.

Conclusion Cytoreduction and hyperthermic intraperitoneal chemotherapy in selected patients with peritoneal carcinomatosis from endometrial cancer achieves promising outcomes concerning the disease free and overall survival.

Disclosure Nothing to disclose.

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