Introduction/Background This study was designed to compare the diagnostic value of Pipelle endometrial sampling with curettage in patients with postmenopausal bleeding and if hysterectomy was done for patients evaluating its pathology with these data’s.

Methodology Eightyseven patients with postmenopausal bleeding were included in this comparison study. Pipelle sampling endometrial biopsy in office for patients was done at first and maximum 4 weeks later they were transferred to operation room for Dilatation and Curettage. The pathology result of Pipelle sampling was compared with curettage as the gold standard was curettage sampling and if hysterectomy was done for patients this data was compared.

Results 100% of samples given by curettage while 97.6% of the samples given by Pipelle were satisfactory for pathological evaluation. Pathological results revealed hyperplasia without atypical in 12 specimens by both methods; while hyperplasia with atypia for 3 patients again in both methods of sampling. Endometrial polyps in 13 for curettage group versus 5 cases in pipelle and malignant endometrium in 13 specimens. 25 patients had hysterectomy surgery and pathological result of 17 specimens revealed malignancy. The Pipelle device had 97.7%sensitivity and 97.7% positive predictive value in diagnosing endometrialmalignancy. Also it had 92.2% sensitivity and 100% specificity for diagnosing endometrial polyp.

Conclusion The endometrial sampling with Pipelle is a safe and cost effective in patients with postmenopausal bleeding which avoids general anesthesia and hospitalization. This method has a high sensitivity and specificity for detection of endometrial hyperplasia and malignancy.

Disclosure Nothing to disclose.