Introduction/Background This study aims to investigate whether the genotype distribution of p53 codon 72 may be a risk factor for endometrial cancer among Moroccan women.
Methodology Samples from 20 Moroccan women, 6 diagnosed with endometrial cancer and 14 healthy controls were used. HPV detection was done by nested PCR with MY09/11 and GP5+/6+ primers followed by sequencing for HPV genotyping. p53 codon 72 polymorphism determination was performed by allele-specific PCR assay. Viral DNA was detected in 16,6% of cases and 14,2% of control. HPV 16 was the most predominant in cancer and controls cases.
Results The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes was 33.2%, 49.8% and 16.6% in the endometrial cancer group and 21.4%, 71,4% and 7,14% in the control group.
Conclusion No significant association was found between polymorphism of p53 itself as well as in combination with HPV16/18 infection and risk of development of endometrial cancer among Moroccan women. Thus, the polymorphism of p53 codon 72 in exon 4 does not seem to play a role in the development of endometrial cancer among Moroccan women.
Disclosure Nothing to disclose.
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