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EP471 Molecular analysis of p53 codon 72 polymorphism among women with endometrial cancer in morocco: a case-control study
  1. B Amal1,
  2. B Mustapha2,3,
  3. EK Mohammed2,3 and
  4. E Moulay4
  1. 1Gynecology Obstetrics, Mohamed VI University of Health Sciences
  2. 2Gynecology Obstetrics, Faculty of Medicine and Pharmacy, Hassan II University
  3. 3Oncology, Mohamed VI Oncology Center, Ibn Rochd Hospital, Casablanca
  4. 4Laboratory of Virology, Microbiology, Quality and Biotechnologies/Biodiversity and Ecotoxicology, Faculty of Sciences and Techniques of Mohammedia, Hassan II University, Mohamedia, Morocco


Introduction/Background This study aims to investigate whether the genotype distribution of p53 codon 72 may be a risk factor for endometrial cancer among Moroccan women.

Methodology Samples from 20 Moroccan women, 6 diagnosed with endometrial cancer and 14 healthy controls were used. HPV detection was done by nested PCR with MY09/11 and GP5+/6+ primers followed by sequencing for HPV genotyping. p53 codon 72 polymorphism determination was performed by allele-specific PCR assay. Viral DNA was detected in 16,6% of cases and 14,2% of control. HPV 16 was the most predominant in cancer and controls cases.

Results The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes was 33.2%, 49.8% and 16.6% in the endometrial cancer group and 21.4%, 71,4% and 7,14% in the control group.

Conclusion No significant association was found between polymorphism of p53 itself as well as in combination with HPV16/18 infection and risk of development of endometrial cancer among Moroccan women. Thus, the polymorphism of p53 codon 72 in exon 4 does not seem to play a role in the development of endometrial cancer among Moroccan women.

Disclosure Nothing to disclose.

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