Introduction/Background We describe the cases of recurrence in endometrial carcinoma with sentinel lymph node biopsy (SLNB) study and analyze possible factors associated with recurrence.
Methodology Retrospective cohort study of patients with recurrent endometrial carcinoma in whom SLNB was performed between 2012-2018. Hysterectomy, double adnexectomy and SLNB were performed by laparoscopy in stages IA G1-G2; while in stages IA G3 and above, we added pelvic and para-aortic lymphadenectomy.
Factors that may associate with recurrence were analyzed: high tumor grade (G3), lymphovascular space invasion (LVSI), myometrial infiltration (MI) >50% and positive SLNB.
Kaplan-Meier curves, long-rank test and Cox regression were used for statistical analysis.
Results We followed 159 patients. Recurrence rate was 7.5%. Mean age was 68.4 years (SD=10.5), BMI 29.4 (SD=4.9) and tumor size 41.2 mm (SD=15.2).
Of the 12 recurrences, 6 were serous (50%), 4 endometrioid (33.3%) and 2 clear cell subtype (16.7%). 9 were G3 (75%), in 4 patients (33.3%) MI was >50% and 5 (41.7%) had LVSI. 3 (25%) and 2 (16.7%) patients had positive pelvic and aortic SLNB respectively. In terms of location of the recurrence, 7 (58.3%) were vaginal and 2 (16.6%) abdominal. The rest were peritoneal, pulmonary and hepatic.
The mean number of months until recurrence was 12.6 (SD=9.6) and the median was of 9 months [95% CI; 7.3-10.7]. 83% relapsed within the first year of postoperative follow-up (SD=0.11)and none recurred after 2 years.
No association was found between lower survival and none of the prognostic factors marked.
Conclusion Recurrence rate of endometrial cancer intervened in SLNB study was 7.5%, being mostly serous adenocarcinoma or G3. 83% recurred within the first year of postoperative control. No association was found between lower survival and none of the possible factors indicated.
Disclosure Nothing to disclose.
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