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EP458 Does HPV type affect the rate of positive surgical margin after cervical cone excision?
  1. YE Purut1,
  2. S Akiş1,
  3. E Keleş1,
  4. M Api1,
  5. C Kabaca Kocakuşak1,
  6. Y Ceylan2,
  7. B Giray1 and
  8. M Güray Uzun1
  1. 1Gynecologic Oncology, Zeynep Kamil Training and Research Hospital
  2. 2Medicine, Istanbul Medipol University, Istanbul, Turkey


Introduction/Background Targeted to find the correlation between HPV types and surgical margin positivity in patients exposed the excisional procedure for treatment of precancerous cervical pathologies.

Methodology We investigated retrospectively 453 patients who recommended Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (CKC) between April-2016 and December-2018. The surgical margin was also examined and separately analysed in patients with a surgical margin less than 1-mm. Pre-procedural HPV type and endocervical curettage results, number of surgical specimen pieces, age, and depth of surgical material were recorded. Post-cone sampling of the endocervical canal was performed. HPV types divided into 6 groups as type-16 only, type-18 only, type-16 and type-18 together, other high-risk HPV types (HR-HPV), type-16 and HR-HPV together, type-18 and HR-HPV together.

Results We performed LEEP in 72 patients and CKC in 376 patients. The mean age was 41.6 years. The surgical margin was positive in 22 patients that underwent LEEP, while in 153 patients that underwent CKC while 1-mm close margin positivity taken into account. Patients (38%) had at least cervical intraepithelial neoplasia (CIN)-1 in the endocervical canal. High-risk types (except 16/18) were presented in 133 patients. Surgical margin positivity was found to be unrelated with the type of HPV in patients either 1-mm close proximity was considered to be positive or negative.

Conclusion No significant difference was found between LEEP and CKC in terms of surgical margin positivity. In addition, there was no significant difference between HPV groups in terms of surgical margin positivity. Patients' age and the presence of multiple pieces of material had no effect on the surgical margin positivity. There was a relationship between the presence of CIN-1 and higher lesions in the endocervical canal and positive surgical margins. Interestingly, CIN (any grade) in the endocervical canal was more common in the other HR-HPV group excluding type-16/18.

Disclosure Nothing to disclose.

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