Introduction/Background To investigate CA-125 levels in uterine papillary serous carcinoma (UPSC) patients.
Methodology From January 2015 to December 2018, we collected data of UPSC and preoperative CA-125 levels of patients. Subsequent parameters were evaluated; age, preoperative endometrial sampling results, tumor size, lymph node involvement, LVSI, depth of myometrial invasion, stage.
Results For the final analysis, 25 patients were eligible. Mean and %95 confidence interval for CA-125 levels in UPSC patients was 130.56 IU/ml (%95 CI: 5.18–255.93). Minimum was 4 and maximum was 1454 IU/ml (median=19). Mean age was 63.04 + 8.7. In lymph node positive patients mean CA-125 was 114.8 IU/ml and lymph node negative patients 134.5 IU/ml (p=0,9). In patients with LVSI mean CA-125 level was 170.73 IU/ml and patients that didn't present with LVSI 76.77 IU/ml (p=0.77). There was no relationship between the tumor size and CA-125 level (Pearson coefficient 0.069, p=0,745). In patients with more than %50 myometrial invasion, mean CA-125 level was 137.66 IU/ml and was less than 50% 126.56 IU/ml (p=0.932). Mean CA-125 level for tumors that were spread beyond the uterus were 257.08 IU/ml and for the tumors that were confined to the uterus were 13.76 IU/ml (p=0,043).
Conclusion Our results suggest that, preoperative CA-125 levels is a good predictor for extrauterine involvement and for advanced stage. There was no correlation between CA-125 and LVSI, lymph node positivity, myometrial invasion, age.
Disclosure Nothing to disclose.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.