Introduction/Background To evaluate the change of cervical length and the best timng for pregnancy after cervical conization in patients with cervical intraepithelial neoplasia (CIN).

Methodology This was a prospective study including patients under 40 years with fertility desire treated by cervical conization for CIN. To assess the cervical length, the patients were divided into two groups according to different surgery procedure: loop electrosurgical excision procedure (LEEP) and cold knife conization (CKC). Patients with cervical length <2.5 cm in CKC group were divided into two groups according to whether receiving cervical cerclage.

Results In LEEP group, the cervical length preoperative was significantly longer than 3 months postoperatively (3.03±0.45 cm VS. 2.84±0.44 cm, p<0.001). The cervical length at 6 and 9 months post-operation (2.97±0.51 cm and 3.01±0.41 cm) present no statistical significance compared to that in pre-operation. In CKC group, the cervical length preoperative was significantly longer than 3 and 6 months postoperatively (2.90±0.41 cm VS. 2.43±0.43 and 2.68±0.41 cm, respectively, p<0.001). No statistical significance was seen between the rest of months preoperatively and postoperatively. Cervical length was significantly longer at 12 months and 9 months after cerclage compared to that without cerclage. 18 patients got pregnant in LEEP group, among which one was pregnant at 5 months postoperatively and had premature delivery. There was one inevitable abortion and one preterm birth among 39 pregnant patients from CKC group.

Conclusion Patients who have fertility desire with CIN were recommended for pregnancy at 6 and 9 months after LEEP and CKC, respectively. Cerclage effectively prolonged cervical length in patents with that less than 2.5 cm to prevent cervical incompetence.

Disclosure No conflict.