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EP419 Efficiency of sentinel lymph node detection with indocyanine green in patients with early stage of cervical cancer. Single-institutional experience, n=80
  1. H Mkrtchyan1,
  2. E Ulrikh1,2,
  3. N Mikaya1,
  4. A Sidoruk1,2,
  5. A Urmancheeva1,2 and
  6. I Berlev1,2
  1. 1National Medical Research Center of Oncology named after N.N. Petrov
  2. 2North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation


Introduction/Background Staging lymphadenectomy in cervical cancer (CC) patients is an enforced feasibility, that could be accompanied with long lasting complications impairing the quality of life of the patients. Sentinel lymph node (SLN) mapping with Indocyanine Green (ICG) in patients with early stage of cervical cancer could help to avoid these problems. The safety and efficacy of this procedure was investigated in 80 CC patients treated in National Medical Research Center of Oncology named after N. N. Petrov through the 5-year period.

Methodology From January 2015 to April 2019 the Data of 80 patients with CC IA1 (with LVSI), IB1, IIA1 stages undergoing minimally invasive surgery and SLN mapping with ICG were analysed in prospective single-center study (National Medical Research Center of Oncology named after N.N.Petrov).

Results Overall detection rate of SLNs registered in 78/80 patients (97.5%), bilateral - 64/78 (82.0%). SLNs were not detected only in 2/80 patients (2.5%). Lymph node metastasis were diagnosed in 11/80 patients (13.75%), of which 10 were in SLNs (87.5%).

Only in one case metastasis was found in the pelvic lymph node, which was not SLN (1.28%) with IB1 stage CC with clear cell morphological type of the tumor.

The most frequent localisation of SLN was the internal lymphatic group near the bifurcation of common iliac artery - 99/176 (56.2%).

Diagnostic efficiency of the SLN biopsy: sensitivity - 90.90%, specificity -87.34%, accuracy - 86.25%, false-negative results - 1.25%.

Conclusion SLN mapping with ICG in patients with CC IA1 (LVI) - IB1, IIA1 stages is an effective and safe diagnostic method that allows with high detection rate visualise SLNs, make biopsy, correctly stage the disease, change the surgical plan and individualise treatment for each patient.

Disclosure Nothing to disclose.

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