Introduction/Background To compare the association of high-risk Human Papilloma Virus (HR-HPV) positivity with abnormal colposcopy findings in women with Atypical Squamous Sells of Undetermined Significance (ASCUS) cervical smear result.
Methodology In this retrospective study, we analyzed the colposcopy findings and the pathology results of the women who had a smear result of ASCUS and HPV test between January 2011 and January 2019 in Acibadem MAA University.
Pap smear was performed using liquid-based cervical cytology (ThinPrep (UHA; Hologic Corp.). HPV tests results were reported as negative or HPV 16 and/or HPV 18 positive or non-16/non-18 positive (positivity of HPV Type 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68).
Colposcopic examination results were grouped into 2 categories: normal and abnormal findings (acetowhite epithelium, mosaic epithelium, leucoplasia and presence of atypical vessels). Biopsies were taken from the abnormal finding areas, histologic evaluations were defined as normal, cervical intraepithelial neoplasia (CIN) 1, CIN2 and CIN3.
The SPSS software version 23.0 (SPSS, Armonk, NY, USA) was used for analyzing data. Pearson Chi-Square tests for contingency tables were used to assess the associations between categorical variables. Statistical significance was set at 0.05 for p value.
Results Among the 61 patients, HPV test results were 13(21%), 23(38%), 25 (41%) for HPV negative, HPV 16/18 positive and non-16/18 positive, respectively. Colposcopic biopsy results were; 28(46%), 21(35%), 9 (15%) and 3(5%) for normal, CIN1, CIN2 and CIN3, respectively. No significant association was observed between the patterns of abnormal colposcopic findings with 16/18 or non-16/18 HPV positive test result (p>0.05). The finding of mosaic pattern during the colposcopy was significantly associated with CIN when compared with asetowhite finding (p<0.05). and also, HPV positivity was significantly associated with CIN1-2-3 (p<0.05). Table 1.
Conclusion Abnormal colposcopic findings does not differ between the high risk HPV subtypes infection.
Disclosure Nothing to disclose.
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