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EP378 Prognostic importance of lymph node in early cervical cancer
  1. J Park
  1. Obstetrics and Gynecology, Dong-A University Hospital, Busan, Republic of Korea


Introduction/Background The purpose of this study was to determine the significance of the positive pelvic lymph node (PLN) metastasis on progression-free survival (PFS) and overall survival (OS) of early cervical cancer patients. The values of other known poor prognostic factors were also analyzed for prediction of the disease prognosis.

Methodology The stage 1A-IIA 245 cervical cancer patients from 1998 to 2014 who underwent radical surgery were retrospectively reviewed. All of the patients underwent radical hysterectomy. Unilateral or bilateral salpingo-oophorectomy was performed considering their age and the stage. PLN dissection was performed when the nodes were suspicious for malignancy from radiologic evaluation or clinical examination. Adjuvant therapy was decided by the patient‘s risk factors.

Results Of the 245 patients, 39 patients had PLN metastasis. 15 patients had one PLN metastasis, and 24 patients had more than 2 PLN metastasis. The multivariate analysis of the prognostic factor, the size (P=0.0198), the number of PLN metastasis (P=0.0005) and the LVSI (P=0.0429) had significant association with PFS. Regarding OS, the number of PLN metastasis (P=0.0044) and stromal invasion (P=0.0427) were significantly associated with OS. Notably the presence of the PLN metastasis was not significant to both PFS and OS, however when specified by the number of PLN metastasis, significant association in both PFS and OS was identified (P=0.0005 and 0.0044 each).

Conclusion We found that tumor size, existence of LVSI, and number of PLN metastasis independently associated with recurrence of the early cervical cancer who underwent surgical treatment. Particularly the number or the PLN metastasis in early cervical cancer has significant association with both recurrence and survival. This result can help assessing PFS and OS and deciding treatment modality of each patient.

Disclosure Nothing to disclose.

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