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EP346 The prognostic value of hematologic parameters in cervical cancer patients receiving radiation therapy
  1. YJ Kim1,
  2. YS Kim2,
  3. KB Lee3,
  4. JW Shin3 and
  5. SH Lee4
  1. 1Gachon University College of Medicine
  2. 2Internal Medicine
  3. 3Obstetrics and Gynecology
  4. 4Radiation Oncology, Gachon University College of Medicine, Incheon, Republic of Korea


Introduction/Background The aim of this study was to determine the prognostic roles of hematologic parameters in patients with cervical cancer received definitive radiation therapy (RT).

Methodology A total of 128 patients received definitive RT for cervical cancer were enrolled in this study.The clinical data and hematologic parameters were retrospectively reviewed, and analyzed their prognostic roles for survival.Theneutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR)) and the changes between pre- and post-treatment in hematologic parameters (ΔNLR, ΔPLR, and ΔLMR) were alsocalculated to analyze the specific roles for survival.

Results The median follow-up was 36.9 months, with a range of 1–114 months.The 5-year overall survival rate and progression free survival rate was 65.8% and 46.4%, respectively. High pretreatment NLR (NLR>2.84) was a poor prognostic factor for progression-free survival (PFS; HR=2.789; 95% CI 1.497–5.197) and overall survival (OS; HR=4.191, 95% CI 2.002–8.773). ΔNLR>0 was significantly associated with lower progression-free survival(HR=2.942, 95% CI 1.458–5.938) and overall survival (HR=3.802, 95% CI 1.487–9.725). In addition to NLR and ΔNLR, age (age≤55; PFS: HR=2.538; 95% CI 1.491–4.320; OS: HR=3.475; 95% CI 1.652–7.310) and FIGO stage (III–IV; PFS: HR=3.067; 95% CI 1.790–5.253; OS: HR=4.252; 95% CI 1.974–9.157) were identified as poor predictors of PFS and OS, whereas white blood cell (WBC<5710; PFS: HR=1.961; 95% CI 1.044–3.682) was significantly predictive of PFS only.

Conclusion Both pretreatment NLR and ΔNLR were independent prognostic factors for cervical cancer patients treated with RT. Risk scoring system-based prognostic factor analysis could be used to help develop optimized treatment plans for cervical cancer patients receiving RT.

Disclosure Nothing to disclose.

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