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EP336 Glassy cell carcinoma of the uterine cervix. A rare and aggressive entity
  1. N Koufopoulos1,2,
  2. F Antoniadou2,
  3. E Karopoulou3,
  4. A Karampelas3,
  5. S Kokkali4,
  6. A Grivas5,
  7. D Papatheodorou3 and
  8. L Khaldi2
  1. 12nd Pathology Department, Attikon University Hospital, National and Kapodistrian University of Athens
  2. 2Pathology Department
  3. 3Gynecology Department
  4. 41st Medical Oncology Department
  5. 52nd Medical Oncology Department, ‘Saint Savvas’ Anticancer Hospital of Athens, Athens, Greece


Introduction/Background Glassy cell carcinoma (GCC) of the uterine cervix is a poorly differentiated subtype of adenosquamous carcinoma. It accounts for 1–2% of cervical carcinomas. It has been associated with high-risk human papillomavirus infection (HPV 16, 18 and 32). We present a case of this rare entity.

Methodology A 46-year-old patient was admitted to the gynecology department. She had a previous diagnosis of poorly differentiated carcinoma on cervical biopsy performed due to an abnormal enlargement of the uterine cervix on routine ultrasound examination. Radical hysterectomy with bilateral pelvic lymph node dissection and omentectomy was performed. On gross examination, the cervix was barrel-shaped, occupied by a bulky, white-gray exophytic mass measuring 60 mm in its greatest dimension.

Results On microscopic examination, the tumor consisted of solid nests of large, pleiomorphic cells with prominent nucleoli, lacking glandular or squamous differentiation, with ground-glass or finely granular cytoplasm. Several mitoses were identified. Tumor nests were embedded in a heavy inflammatory infiltrate. Immunohistochemically tumor cells showed positive staining for EMA, Vimentin, P16, pCEA and negative for CK7, CK20, P63, ER, PR, and HMB45. The omentum and pelvic lymph nodes were tumor free. Our diagnosis based on morphological and immunohistochemical findings was GCC of the uterine cervix. The patient received adjuvant radiotherapy and chemotherapy. She remains disease-free 9 months post surgery.

Conclusion GCC is a clinically aggressive subtype of cervical carcinoma with rapid growth, and early metastases. Treatment consists of surgery followed by radio-chemotherapy or neoadjuvant therapy in cases with advanced disease. Multimodal therapy has improved prognosis in patients with FIGO stage I or II but not in higher stage disease.

Disclosure Nothing to disclose.

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