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EP252 Para-aortic lymph node involvement revisited in the light of the revised 2018 FIGO staging system for cervical cancer: a retrospective, dual-institutional study
  1. A Ayhan1,
  2. K Aslan2,
  3. M Oz3,
  4. YA Tohma1,
  5. E Kuscu1 and
  6. MM Meydanli2
  1. 1Obstetrics and Gynecology, Baskent University Faculty of Medicine
  2. 2Gynecologic Oncology, Zekai Tahir Burak Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences
  3. 3Gynecological Oncology Unit, Meir Medical Center, Ankara, Turkey


Introduction/Background This dual-institutional, retrospective study aimed to determine the clinicopathological risk factors for para-aortic lymph node (LN) metastasis among women who underwent radical hysterectomy with systematic pelvic and para-aortic lymphadenectomy for 2009 FIGO stage IB1-IIA2 cervical cancer.

Methodology Institutional cervical cancer databases of two high-volume gynecologic cancer centers in Ankara, Turkey were retrospectively analyzed. Those featured in the study included women with 2009 FIGO stage IB1-IIA2 disease who underwent radical hysterectomy with pelvic and para-aortic lymphadenectomy between January 2006 and December 2018. We analyzed the patient data and investigated all potential predictive factors for para-aortic LN metastasis.

Results A total of 522 women met the inclusion criteria. Pelvic LN metastasis was detected in 190 patients (36.4%); para-aortic LN metastasis in 48 patients (9.2%), isolated para-aortic LN metastasis in 4 (0.8%), and both pelvic and para-aortic LN metastasis in 44 (8.4%) women, respectively. The independent risk factors identified for para-aortic LN involvement included parametrial invasion (odds ratio [OR]: 3.57, 95% confidence interval [CI]: 1.65–7.72; p=0.001), metastasized pelvic LN size >1 cm (OR: 4.51, 95% CI: 1.75–11.64; p=0.002), multiple pelvic LN metastases (OR: 3.83, 95% CI: 1.46–10.01; p=0.006), and common iliac LN metastasis (OR: 2.97, 95% CI: 1.01–8.68; p=0.04). A total of 196 (37.5%) patients exhibited at least one risk factor for para-aortic nodal disease.

Conclusion Parametrial invasion, metastasized pelvic LN size >1 cm, multiple pelvic LN metastases, and common iliac LN metastasis seem to be independent predictors of para-aortic LN involvement.

Disclosure Nothing to disclose.

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