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EP231 ER, PR and HER-2 status in breast cancer – correlation with clinicopathological characteristics and clinical outcome at a tertiary care centre in south india
  1. D Shunmugam1 and
  2. A Velappan2
  1. 1Surgical Oncology
  2. 2Medical Oncology, Tirunelveli Medical College Hospital, Tirunelveli, India


Introduction/Background Breast cancer has now overtaken cervical cancer to become leading cancer among women in India. The AJCC Staging Manual has included grade and ER, PR and HER-2 status in the Prognostic Stage Grouping thus emphasizing their importance. The main objective of this study was to assess the ER, PR and HER-2 status among breast cancer patients and find out its correlation with age, histological type, grade and stage.

Methodology In this retrospective study, records of 548 patients in the Medical Oncology Department at Tirunelveli Medical College Hospital were reviewed. Data were analyzed using the Pearson Chi-square test, One-way ANOVA and Kendall tau test. Survival analysis was done using Kaplan- Meier estimator.

Results The average age at diagnosis was 51.56 years, 70.8% (n=388) belonged to stage III. The most common histological type and grade was Infiltrating Ductal Carcinoma not otherwise specified (94.3%) and Grade II (69.7%, n=382) respectively. The hormone receptor (HR) positive patients constituted about 38.3% (n=210), triple negative breast cancer (TNBC) patients about 27.2% (n=149) and HER-2 positive patients included 34.5% (n=189). Among the HER-2 positive patients, 40.2% (n=76) were also HR positive. The HR-positive patients (53.87) were diagnosed at a later age compared to hormone receptor negative patients (49.46) with a P-value=0.001. There was no association between histological type and ER, PR, and HER-2 status. Triple-negative breast cancer patients had more of grade III (34.9%) compared to the HR group (17.1%) (P=0.001). The larger number of HR-positive patients presented at stage II (24.8) compared to others (3.8%)(P=0.001). More number of HER-2 positive patients (27.5%) presented in stage IV than others (11.7%) (P=0.001).

Conclusion TNBC an aggressive subtype was more common in Indians compared to the western population. HR positive status was associated with older age, lesser grade and stage at diagnosis and hence have a better prognosis.

Disclosure Nothing to disclose.

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