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EP229 Breast metastasis from a renal cell cancer. Case report and literature review
  1. I Sassi1,
  2. N Lamia1,
  3. A Bouida1,
  4. O Jaidane1,
  5. H Bouaziz1,
  6. S Kammoun2,
  7. M Slimen1,
  8. O Adouni2,
  9. M Hechiche1,
  10. R Chargui1 and
  11. K Rahal1
  1. 1Surgical Oncology Department
  2. 2Pathology Department, Institute Salah Azaiez, Tunis, Tunisia


Introduction/Background Metastases to the breast from extramammary tumours are uncommon representing about 0.2% to 1.3% of malignant tumours in the breast. Metastatic renal cell carcinoma to the breast is extremely rare.

Methodology We report the case of a female patient treated in our institute in 2019.

We reviewed publications since 1998 to date, using PubMed and Sciencedirect.

Results A 60 years-old woman with a medical history of renal carcinoma treated by radical nephrectomy. After 7 years of follow-up, CT scan revealed a right breast lump. Clinical examination found a 2cm hard lump, poorly defined at the union of the upper quadrants of the left breast. A mammography showed a round, relatively circumscribed and intermediate density mass. No calcification was identified. Ultrasonography showed a hypoechogenic, solid vascular mass (1.6*1.4cm) in the left breast and similar intramuscular lesion in the axillary tail of the right breast. No pathological axillary adenopathies were identified. Tumour was classified BIRADS 4.An ultrasound-guided needle biopsy was performed for both left and right lesions. Histopathological examination showed polygonal cells containing clear cytoplasm. Immunohistochemistry revealed that the tumour cells were positive for CD10 and vimentin and negative for oestrogen receptors (ER),progesterone receptors (PR) and cytokeratine CK7. The morphology and immunoprofile were consistent with a metastatic renal clear cell carcinoma.

The case was discussed in the multidisciplinary meeting. Surgery was ruled out and the patient was referred to the medical oncology department to start systemic treatment.

Conclusion A positive diagnosis of the metastasis from extramammary lesion is crucial to provide proper treatment and avoid unnecessary surgery.

Disclosure Nothing to disclose.

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