Introduction/Background In a previous pilot study we found that polyunsaturated n-3 fatty acids of marine origin were associated with Breast cancer multifocality. In the present study, we aimed to confirm these results altogether with investigating clinical and histological factors associated with breast cancer focality in a larger cohort of women with positive hormone-receptors breast cancer.

Methodology One hundred sixty-one consecutive women presenting with non-metastatic breast cancer with positive hormone-receptors underwent breast-imaging procedures including a Magnetic Resonance Imaging prior to treatment. Breast adipose tissue specimens were collected during surgery. We established a biochemical profile of adipose tissue fatty acids by gas chromatography. Clinicopathologic characteristics were correlated with multifocality. We assessed whether these factors were predictive of breast cancer focality.

Results We found that tumor size (OR=1.06 95%CI[1.02– 1.09], p<0.001) and decreased levels in breast adipose tissue of long-chain polyunsaturated n-3 fatty acids (OR=0.11 95%CI[0.01– 0.98], p=0.03), were independent predictive factors of multifocality.

Conclusion These differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality.

Disclosure Nothing to disclose.