Introduction/Background The purpose of this study is to evaluate the risk of osteopenia and osteoporosis in patients with Gynecologic cancer without bone metastases and to evaluate the impact of surgical treatment, chemotherapy and radiotherapy on bone mineral density(BMD).

Methodology From March 2010 to December 2016, this study retrospectively reviewed the medical records of women who were treated at Haeundae Paik Hospital Obstetrics and Gynecology. We compared the lumbar spine and femur neck BMD of 243 women with gynecological cancer and 240 controls. Patients with cervical cancer (n=105), endometrial cancer (n=63) and ovarian cancer (n=75) were treated with radical hysterectomy with bilateral salpingo-oophorectomy, chemotherapy and radiotherapy. As a control group, women with postmenopausal, who did not diagnosed with gynecologic malignancy were selected.

Results T-scores of cervical cancer patients was significantly lower in L1, L2 and femur neck compared with control before cancer treatment. T-scores of the mean values of lumbar spine and L1-L4 in ovarian cancer patients was significantly lower respectively. On the other hand, T-scores of endometrial cancer patients was not significantly different from the control group.

There was a significant difference in BMD of L3, L4 and femur neck before and after treatment according to treatment method. T-scores change was the smallest in patients who underwent only surgical treatment including bilateral salpingo-oophorectomy, and the T-scores decreased most in patients who underwent postoperative concurrent chemoradiotherapy.

Conclusion The prevalence of osteoporosis in the gynecologic cancer was significantly higher than in the control. BMD of patients with cervical cancer and ovarian cancer before treatment was significantly lower than control, and BMD after cancer treatment was significantly decreased in endometrial cancer. In patients with gynecologic cancer, the reduction of BMD and the risk of secondary osteoporosis and osteoporotic fracture were identified, and efforts should be made to prevent and early diagnose them.

Disclosure Nothing to disclose.