Article Text

Download PDFPDF
P155 The microRNA 34 family and its clinical significance in ovarian cancer
  1. H Welponer1,
  2. I Tsibulak1,
  3. V Wieser1,
  4. C Degasper1,
  5. G Shivalingaiah2,
  6. S Wenzel2,
  7. S Sprung3,
  8. C Marth1,
  9. H Fiegl1 and
  10. AG Zeimet1
  1. 1Gynecology and Obstetrics
  2. 2Division of Human Genetics
  3. 3Institute of Pathology, Medical University Innsbruck, Innsbruck, Austria


Introduction/Background The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of the various miR-34 family members has not been studied in ovarian cancer.

Methodology In 228 ovarian cancers and in 19 non-neoplastic fallopian tube samples we analysed miR-34a/b/c expression in relation to clinicopathological characteristics and clinical outcome.

Results We found significantly lower levels of miR-34a/b/c in ovarian cancers as compared to control-tissues (P=0.002, P<0.001, P<0.001, respectively). Expression of miR-34b/c revealed an inverse correlation with BRCA1/2 mRNA-expression (BRCA1: miR34b/c P=0.002 each; BRCA2: miR-34b/c P<0.001 each), the same was true for miR-34a and BRCA2 mRNA-expression (P<0.001). The miR-34 family expression was found to be significantly lower in type 2 in comparison to type 1 cancers (P<0.001) and in TP53-mutated compared with TP53-wild-type ovarian cancers (P<0.001, P=0.002, P=0.004, respectively). When low grade serous ovarian cancers were compared with high grade serous cancers the respective miR-34a/b/c expression was 2.6-, 40.8- and 32.3-fold higher. The expression of each of the miR-34 family members was revealed to be of independent prognostic relevance regarding progression free survival (miR-34a: HR 0.6, P=0.033; miR-34b: HR 0.2, P=0.001 and miR-34c: HR 0.3, P=0.002, respectively). For overall survival independency of the prognostic value was confined to miR-34b (HR 0.4, P=0.016) and miR-34c (HR 0.6, P=0.049).

Conclusion Our findings suggest that downregulation of miR-34 family is a crucial part in ovarian cancer development. Low miR-34 levels are linked to a worse overall survival and progression free survival and may indicate a more aggressive disease.

Disclosure Nothing to disclose.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.