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P151 Endometriosis and the risk for ovarian cancer
  1. CN Trifan1,
  2. S Pasat1,
  3. D Hutanu1,
  4. SD Tirnovanu2,
  5. C Mucilenita1 and
  6. MC Tirnovanu3
  1. 11st Clinic of Obstetrics and Gynecology, University Women Hospital Cuza Voda Iasi
  2. 2University of Medicine and Pharmacy ‘Gr T Popa’ Iasi
  3. 3Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Gr T Popa’ Iasi, Iasi, Romania


Introduction/Background Despite being initially considered a benign disease, the wide opinion nowaday is that ovarian endometriomas are neoplastic condition with the potential to become malignant.

Objective Our study assess the relationship between endometriosis and clinical features as age, menopausal status, stage for ovarian cancer patients.

Methodology A retro- and prospective analysis was conducted on 323 patients treated by surgery for ovarian cancer (OC) between 2003–2017 in our clinic. The patients records and pathological results were used. Histological classification of OC was based on WHO system and the stage was according to the current FIGO system. The presence of endometriosis was established on resected specimens.

Results The mean age was 49.6±5.2 and 55.2±7.4 years for patients having endometriosis-associated ovarian cancer (EAOC) and OC respectively. From all cases with OC only 25 were associated with lesions of endometriosis: 18 cases with endometrioid epithelial ovarian cancer (from these 5 with synchronous primary endometrioid cancer of endometrium and ovary), 4 with ovarian cancer clear cell, 1 with serous invasive cancer, and 2 patients with mucinous borderline ovarian cancer. From these cases only 6 women had a histology-proven transition from benign endometriosis to atypical endometriosis and cancer. These women were with a long-standing history of endometriosis or with a history of infertility. EAOC was more commenly unilateral (16 cases) and without ascites.

Conclusion In our study 7.74% cases of epithelial ovarian cancer were associated with endometriosis. There was early onset of ovarian cancer for cases having endometriosis of about 5.6years average. Endometriosis lesions may predispose more freqentlly to endometrioid and clear cell invasive ovarian cancer. Women with EAOC are typically premenopausal and have early stage disease. Screening programs for ovarian cancer are not currently effective, but that may change in the future for premenopausal women with endometriosis.

Disclosure Nothing to disclose.

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