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P149 Pregnancy-related risk factors for sex cord-stromal tumors and germ cell tumors in parous women: a registry-based study
  1. C Sköld1,
  2. T Bjørge2,3,
  3. A Ekbom4,
  4. A Engeland2,5,
  5. M Gissler6,7,
  6. T Grotmol3,
  7. L Madanat-Harjuoja8,9,
  8. A Gulbech Ording10,
  9. B Trabert11,
  10. S Tretli3,
  11. R Troisi11,
  12. H Toft Sørensen10 and
  13. I Glimelius1,4
  1. 1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  2. 2Department of Global Public Health and Primary Care, University of Bergen, Bergen
  3. 3Cancer Registry of Norway, Oslo, Norway
  4. 4Department of Medicine, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden
  5. 5Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Bergen, Norway
  6. 6National Institute for Health and Welfare (THL), Helsinki, Finland
  7. 7Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
  8. 8Finnish Cancer Registry
  9. 9Department of Pediatrics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  10. 10Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
  11. 11Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA


Introduction/Background Non-epithelial ovarian cancers are rare but affect women of all ages. The etiology is unknown. Non-epithelial ovarian cancers are divided into two major subgroups: sex cord-stromal tumors (SCSTs) and germ cell tumors (GCTs). Whereas parity is protective for epithelial ovarian cancer, its association with non-epithelial ovarian cancer and its subtypes remains less clear, as are associations with other pregnancy-related factors.

Methodology All parous women with births recorded in the medical birth registries from the Nordic countries with a subsequent diagnosis of SCSTs (n=420) and GCTs (n=345) during 1967–2013 were compared with up to 10 controls (SCSTs n=4041; GCTs n=2942) matched on the cases’ birth year and country. We used conditional logistic regression to estimate odds ratios (ORs)with 95% confidence intervals (CI)of associations of pregnancy-related factors.

Results Number of births was not associated with risk of SCSTs or GCTs. Older age at last birth was inversely associated with the risk of SCSTs (age 30–39 versus <25 years: OR 0.64, 95% CI 0.45–0.90). The risk decreased gradually with increasing age at birth. Shorter time since first or last birth was also inversely associated with SCSTs. None of the investigated factors were associated with GCTs.

Conclusion In this large population-based case-control study among parous women, number of births was not protective for risk of SCSTs and GCTs.The inverse associations with greater age at last birth and shorter time since last birth observed for SCSTs, however, suggest that these subtypes may be influenced by the woman’s reproductive history.

Disclosure Ingrid Glimelius have received Honoraria from Janssen for projects unrelated to the current study.

Abstract P149 Table 1

Age at last birth and risk of non-epithelial ovarian cancer by subtype

Abstract P149 Table 2

Time since last birth and risk of non-epithelial ovarian cancer by subtype

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