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P143 Risk factors for early death among ovarian cancer patients – a nationwide cohort study
  1. B Mosgaard1,
  2. A Meaidi1,
  3. C Hogdall2 and
  4. M Noer2
  1. 1Gynecology, University of Copenhagen – Rigshospitalet
  2. 2JMC, Rigshospitalet, København Ø, Denmark


Introduction/Background Denmark has, along with the UK, for many years ranked at the bottom of the statistics regarding ovarian cancer survival. Considering ovarian cancer survival curves, Denmark distinguishes itself by having a steep fall in survival during the first 0–6 months, after which the survival curve is parallel to the curves of the other countries. This high short-term mortality may be the primary explanation for the overall poor prognosis of Danish ovarian cancer patients.

Objective To characterise ovarian cancer patients who die within six months of diagnosis and to identify prognostic factors for these early deaths.

Methodology A nationwide cohort study covering women diagnosed with ovarian, fallopian tube, or primary peritoneal cancers in Denmark in 2005–2016.

Results A total of 5,570 patients were included. Three months after ovarian cancer diagnosis 456 (8.2%) had died and 664 (11.9%) died within six months of diagnosis. Adjusted for age and comorbidity, patients who died early were admitted to hospital significantly more often in a six-month period before the diagnosis (OR 1.61 (1.29–2.00), and OR 1.47 (1.21–1.78)), for patients who died within three and six months respectively). Low educational level, low income and singlehood were factors significantly associated with higher risk of early death.

The discriminative ability of the risk factors family type, employment, income, comorbidity, BMI, admission to hospital due to pain or thromboembolism, tumour stage, performance status, cancer treatment, histology, and residual tumour in identifying early death was assessed by cross-validated area under the receiver operating characteristic curve (AUC). The AUC was found to be 0.91 (0.88–0.93) and 0.90 (0.87–0.92) for death within 3 and 6 months respectively.

Conclusion Our study found that 90–91% of deaths within six months from the ovarian cancer diagnosis could be predicted upon admission to the gynecologic department by including known patient- and tumour-related risk factors.

Disclosure None of the authors have conflicts of interest.

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