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P136 Risk factors for anastomotic leakage after colorectal resection in ovarian cancer surgery: a multi-centre study
  1. V Lago1,
  2. C Fotopoulou2,
  3. V Chiantera3,
  4. L Minig4,
  5. A Gil-Moreno5,
  6. PA Cascales-Campos6,
  7. M Jurado7,
  8. Á Tejerizo8,
  9. P Padilla-Iserte1,
  10. ME Malune2,
  11. MC Di Dona9,
  12. T Marina10,
  13. JL Sanchez-Iglesias5,
  14. A Olloqui8,
  15. Á García-Granero1,
  16. L Matute1,
  17. V Fornes11 and
  18. S Domingo1
  1. 1University Hospital La Fe, Valencia, Spain
  2. 2Imperial College London, London, UK
  3. 3University of Palermo, Palermo, Italy
  4. 4CEU Cardenal Herrera University, Valencia
  5. 5University Hospital Vall d’Hebron, Barcelona
  6. 6Virgen de la Arrixaca Clinic and University Hospital, Murcia
  7. 7University Clinic of Navarra, Navarra
  8. 8University Hospital 12 de Octubre, Madrid
  9. 9University of Palermo, Palermo
  10. 10Valencian Institute of Oncology
  11. 11Health Research Institute Hospital La Fe, Valencia, Spain


Introduction/Background In advanced ovarian cancer surgery, there is rather limited published evidence, drawn from a small sample, providing information about risk factors for anastomotic leak.

Methodology To determine pre-/intraoperative risk factors for anastomotic leak after modified posterior pelvic exenteration (MPE) or colorectal resection in ovarian cancer and to create a practical instrument for predicting anastomotic leak risk. Eight hospitals participated in this retrospective study. Data on 695 patients operated for ovarian cancer with primary anastomosis were included (January 2010-June 2018). Twelve pre-/intraoperative variables were analysed as potential independent risk factors for anastomotic leak. A predictive model was created to stablish the risk of anastomotic leak for a given patient.

Results He anastomotic leak rate was 6.6% (46/695; range 1.7%–12.5%). A total of 457 patients were included in the final multivariate analysis. The following variables were found to be independently associated with anastomotic leakage: age at surgery (OR 1.046, 95% CI 1.013–1.080, p = 0.005), serum albumin level (OR 0.621, 95% CI 0.407–0.948, p = 0.027), one or more additional small bowel resections (OR 3.544, 95% CI 1.228–10.23, p = 0.019), manual anastomosis (OR 8.356, 95% CI 1.777–39.301, p = 0.007) and distance of the anastomosis from the anal verge (OR 0.839, 95% CI 0.726–0.971, p = 0.018).

Conclusion Due to the low incidence of AL in ovarian cancer patients, a restrictive stoma policy based on the presence of risk factors should be the actual recommendation. Hand-sewn anastomosis should be avoided.

Disclosure Nothing to disclose.

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