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P94 Nature of early stage endometrial cancer recurrence: a cohort study
  1. Z Zubair1,
  2. S Masood2 and
  3. A Ali Syed3
  1. 1Skmhc Lahore | Gynaecological Oncology | Surgical Oncology, Shaukat Khanummemorial Hospital and Research Centre Lahore
  2. 2Student, King Edward Medical University Lahore
  3. 3Surgical Oncology, Skmch, Lahore, Pakistan


Introduction/Background Evidence regarding rise of endometrial carcinoma is on uprise which is highlighting the need of appropriate surveillance after the primary treatment. So the study was planned to analyze disease recurrence in cohort of women with early stage endometrial cancer and associated clinico-pathological and sociodemographic predictors of disease recurrence.

Methodology All the women dignosed with stage 1 endometrial cancer in 2009–2013 who underwent hysterectomy were included in a hospital based cohort derived from database at SKMCH Lahore. Disease recurrence upto 3 years after the primary diagnosis was assessed and follow up on survival was completed on 31 december 2017. Predictive value of clininco- pathological and socio demographic variables was evaluated.

Results With in 3 years of primary treatment recurrence identified in 13( 5.2%) of the included 250 women. Predictive factors for recurrence included International Federation of Gynaecology and Obstetrics (FIGO) stage (OR 1.89 1B), Charlson comorbidity index of 3(OR: 1.88) and non endometrial histology (OR 1.77). Overall survival was significantly affected by site of recurrence. 5 year survival was 75% for women with vaginal recurrence and only 15% in women with the distant metastasis.

Vaginal recurrence was predicted by FIGO stage only (OR: IB 1.66), while extra-vaginal recurrence was predicted by FIGO stage(OR: IB 1.88 )Charlson comorbidity index of 3(OR 1.77) and non-endometrioid histology (OR 2.31).

Conclusion Early stage endometrial carcinoma is associated with a low risk of recurrence with in 3 years after hysterectomy and the site of recurrence is highly predictive of overall survival yet future research should seek to understand the underlying mechanism of these predictive factors so as to reduce the morbidity and mortality.

Disclosure Nothing to disclose.

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