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170 Patterns of recurrence after robotic-assisted radical hysterectomy (RRH) for early stage cervical cancer (CC)
  1. C Fitzsimmons,
  2. A Stephens,
  3. J Kennard,
  4. M Manyam,
  5. J Pepe,
  6. K DeCoff,
  7. S Ahmad,
  8. N McKenzie,
  9. J Kendrick and
  10. R Holloway
  1. AdveHealth Cancer Institute, Gynecologic Oncology, Orlando, USA


Objectives To evaluate the recurrence patterns of early CC following RRH.

Methods Patients with early-stage CC (4/2007–12/2017) who underwent RRH using a uterine manipulator were evaluated. Inclusion criteria: > one year follow-up, adenocarcinoma or squamous carcinoma, stage IA2 or IB1 using FIGO-2014 guidelines, and pathologic tumor size (TS) of ≥4 cm.

Results 144 RRH patients were identified and 90 met inclusion criteria. Baseline characteristics included: TS ≥2 cm 42 (47%) and adenocarcinoma 40 (44%). There were 7 (7.8%) recurrences with median time to recurrence of 12±8.3 months. All recurrences had TS ≥2 cm (median 2.7±0.7 cm). Of the 42 cases with TS ≥2 cm, 14 had adenocarcinoma with 5 (36%) recurrences compared to 28 squamous with 2 (7%) recurrences (p=0.057). Three recurrences had carcinomatosis with mean RFS and OS of 5.3±2.3 and 28.3±30.9 months compared to 17.8±6.3 and 80.6±48.6 months for cases with local/pulmonary metastasis (n=4). RFS with carcinomatosis was less than RFS for local/pulmonary (p=0.014). Six recurrences occurred within the first 10 RRH cases per surgeon.

Abstract 170 Table 1

Conclusions Early-stage CC treated with RRH appears to have a unique pattern of recurrence in some cases with carcinomatosis that results in shortened RFS. Recurrences were associated with adenocarcinoma, TS ≥2 cm, and first 10 cases of surgeon experience. Carcinomatosis may be related to negative insufflation following colpotomy, requiring a new strategy that isolates the cervical tumor prior to colpotomy.

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