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147 Predictive factors associated with successful bilateral sentinel lymph node mapping in early-stage cervical cancer
  1. A Bresset1,
  2. V Balaya1,
  3. L Magaud2,
  4. H Bonsang-Kitzis1,
  5. M Deloménie1,
  6. HT Nguyen-Xuan1,
  7. M Koual1,
  8. R Montero Macias1,
  9. C Ngo1,
  10. AS Bats1,
  11. P Mathevet3 and
  12. F Lécuru1
  1. 1Georges Pompidou European Hospital, Gynecologic and Breast Oncologic Surgery Department, Paris, France
  2. 2Hospices Civils de Lyon, Pôle IMER, Lyon, France
  3. 3Lausanne University Hospital, Gynecology Department, Lausanne, Switzerland


Objectives The objective of this study was to determine clinical, tumor and surgical factors associated with sucessful bilateral sentinel lymph node mapping (SBM) in early-stage cervical cancer.

Methods We performed an ancillary work on the data of two prospective trials on SLN biopsy for FIGO IA-IIA cervical cancer (SENTICOL I & II). Patients having a radical surgery with lymph node dissection were included between 2005 and 2012 from 25 French oncologic centers. Sentinel lymph node (SLN) was detected by a combined labeling technique (blue and isotopic).

Results 326 patients were included for analysis: SLNs were identified on at least one side of the pelvis in 308 patients (97.6%) and bilaterally in 278 patients (85.3%). No SLNs were found in 8 patients (2.4%). The mean age was 43 years [22–85 years]. Most patients (88.1%) had IB1 clinical FIGO stage. The majority of patients (71%) had squamous cells carcinoma. Surgeries were mainly performed by mini-invasive approach (296 patients – 90.8%) whereas 30 patients (9.2%) were operated by laparotomy. By multivariate analysis, SBM was associated with minimal invasive approach (ORa= 15.00, 95%CI = [1.24 – 181.63], p = 0.03) and inclusion during the period 2009–2012 (ORa= 14.81, 95%CI = [3.89 – 56.45], p < 0.0001) compared to the period 2005–2007. Age ≥ 70 years was significantly associated with lower SBM rate (ORa= 0.03, 95%CI= [0.004 – 0.20], p = 0.0002).

Conclusions A better experience of SLN biopsy technique, minimal invasive approach and patient age < 70 years were associated with better SBM rate in early-stage cervical cancer.

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