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138 Selected tumor markers and sex-steroid hormones in breast tumors
  1. I Nakashidze1,
  2. N Kotrikadze2,
  3. E Gogitidze3,
  4. L Ramishvili2,
  5. N Petrovic4,
  6. M Alibegashvili2,
  7. N Kedelidze3,
  8. N Lomtatidze3,
  9. M Koridze3,
  10. B Sepiashvilli2,
  11. D Baratashvili3 and
  12. S Ahmad5
  1. 1Ivane Javakhishvili Tbilisi State University, Scientific–Research Institute of Cellular and Molecular Medicine, Tbilisi, Georgia
  2. 2Ivane Javakhishvili Tbilisi State University, Department of Biology, Tbilisi, Georgia
  3. 3Batumi Shota Rustaveli State University, Department of Biology, Batumi, Georgia
  4. 4Vinca Institute of Nuclear Sciences University of Belgrade, Department for Radiobiology and Molecular Genetics, Belgrade, Serbia
  5. 5Florida Hospital Cancer Institute, Department of Gynecologic Oncology, Orlando- FL, USA


Objectives Breast cancer (BC) is one of the tumors with the highest incidence among women worldwide. We have been investigating potential association between CA153, CA125, and CEA tumor makers,and sex-steroid hormones estrogen (E2), progesterone (P), and testosterone(T).

Methods For the assessment of hormonal status, we used the blood samples of women with benign (fibroadenoma) and malignant tumors of breast gland within patients aged between 20 and 45 years. Also, control group of women were age-matched. Enzyme-linked immunosorbent assay (ELISA) was used for the quantitative determination of hormones, with appropriate ELISA kits. P < 0.05 was regarded as statistically significant.

Results The investigations have shown the levels of CA153, CA125 and CEA tumors markers were high within patients with benign and malignant breast tumors. According to our studies levels of steroid hormones E2 and T were elevated in BC tumors (benign - P<0.0001 and P=0.003; malignant - P=0.0003 and P=0.0424, respectively).

Conclusions In conclusion, the present study suggests that higher levels of CA 15–3, CA 125, CEA tu­mor markers and sex steroid hormones (E2, T) may be useful as a reliable prognostic marker for early breast cancer prevention and diagnostics. The association between mentioned tumor markers and sex-steroid hormones provides a new perspective a identify new combinative markers for breast cancer.

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