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132 Post-mastectomy radiation therapy in node-negative breast cancer
  1. S Haddad,
  2. I Zemni,
  3. O Adouni,
  4. L Acouri,
  5. J Ben Hassouna,
  6. M Hechiche,
  7. R Chargui and
  8. K Rahal
  1. Salah Azaiez Institute, Surgical Oncology, Tunis, Tunisia


Objectives The aim of this study is to identify the clinicopathological features that can possibly indicate PMRT.

Methods We retrospectively reviewed 175 patients with pT1-T2 N0 M0 breast cancer from 2001 to 2003, among them PMRT was delivered in 104 cases.

Results In the group of PMRT the mean age was 49 years old with 12.5% (N=13) young female patients (≤ 35 years old) where as only 2.8% young patients were identified in the group of mastectomy alone (p=0.002). Invasive ductal carcinoma adjacent to area of DCIS was found in 40% (N =71) of cases. Multifocality in the rest of the gland was identified in 32% (N =56) of cases and singificantly influenced the indication of PMRT (p=0.03). unfortunatly. Adjuvant chemotherapy was indicated in 65% 5 (N=114) of cases and it was based on anthracyclin (95%). OS at 3 and 5 years were 85.5 and 69.5% respectively. On univariate analysis, PMRT was not associated with a better OS compared to mastectomy alone. After a mean follow-up period of 62 months disease free survival DFS at 3 and 5 years were 88.1 and 83.6%, nine patients experienced LRR, five patients developped a bilateral tumor and 30 patients had distant metastasis. PMRT did not influence the locoregional and the metastatic status of our population.

Conclusions there is no increase in the risk of distant metastasis, locoregional recurrence, or death when PMRT was omitted in breast cancer patients with p T1-T2N0 M0 status.

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