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402 Clear cell carcinoma of the uterine corpus
  1. I Ben Safta1,
  2. H Mansouri1,
  3. O Jaidane1,
  4. I Zemni1,
  5. N Boujelbene2,
  6. J Ben Hassouna1,
  7. R Chargui1 and
  8. K Rahal1
  1. 1Salah Azaiez Institute, Surgical Oncology, Tunis, Tunisia
  2. 2Salah Azaiez Institute, Pathology, Tunis, Tunisia


Objectives Clear cell (CC) carcinomas are a type 2 endometrial carcinomascharacterized by their rarity (2%) and their aggressive behavior.

Methods This was a retrospective study including 9 cases of CC, recorded at the Salah Azaiez Institute over a period of 16 years (2000–2015). Clinical, pathological and evolutionary data were analyzed.

Results The mean age was 70 years [50–73]. All patients underwent curative resection by laparotomy.Extra-facial hysterectomy was performed in 8 cases and radical hysterectomy in 1 case. Lymph node surgery was performed in all of our patients.Patients were classified according to FIGO 2009: 33.3% were classified stage I, 22.2% stage II, 22.2% stage III and 22.2% stage IV.Lymphovascular space invasion was found in 44.4% of the cases. The median number of retiredlymph node and involved were 10 [1–32] and 2 [1–14], respectively.Two patients received adjuvant chemotherapy, 4patients received adjuvant radiotherapy and vaginal brachytherapy was performed in 5 patients.Median follow-up was 28 months (5–129). The 5-years overall survival were 48.6%.Excluding one patient lost of view after the end of the treatment, 3 patients were in clinical remission, 2 patients were in a progression of their disease, and relapses occurred in the three remain patients.

Conclusions Endometrial CC are an aggressive histological subtype with particular clinical and pathological features leading to a high rate of recurrence and death.

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