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365 Collision tumor in cervix: small-cell neuroendrocrine carcinoma and adenocarcinoma – case report of rare tumor
  1. G Resende1,
  2. B Ruiz2,
  3. J Silva3,
  4. YL Viana4 and
  5. R Camelo5
  1. 1Foundation Center of Oncology Control – FCecon, Department of Clinical Oncology, Manaus, Brazil
  2. 2University Nilton Lins – UNL, Faculty of Medicine, Manaus, Brazil
  3. 3University of Technology of Amazonas – UEA, Department of Surgical Oncology, Manaus, Brazil
  4. 4University of Technology of Amazonas – UEA, Faculty of Medicine, Manaus, Brazil
  5. 5Foundation Center of Oncology Control – FCecon, Department of Pathology, Manaus, Brazil


Objectives We reported a rare case of collision tumor in cervix displaying dual histological component of adenocarcinoma and small cell neuroendocrine carcinoma in a 53-year-old woman.

Methods Collision tumors are the presence of many histological types in a single organ. It have been reported in adrenal, brain, skin, lung, breast, but is unusual in the uterine cervix

Results A 53-year old female who presented abnormal, persistent and small volume of vaginal bleeding. She presented a small ulcerative lesion in the uterine cervix. Subsequently, she underwent a colposcopy with biopsy that showed small-cell neuroendocrine carcinoma and adenocarcinoma. Immunohistochemistry confirmed the findings and revealed positivity for P63, synaptophysin, chromogranin A and vimentin. No distant metastasis are found at CT scan.Total hysterectomy with pelvic lymphadenectomy surgery was performed, which histopathological reported ulcerative lesion in the uterine cervix extending until endocervical canal with 1cm of depth without parametrial involvement. Negative for pelvic lymph nodes and vascular invasion. The patient received adjuvant chemoradiotherapy with cisplatin and etoposide. She did not receive brachytherapy. The patient has been in follow-up without disease evidence.

Conclusions Despite of stage IB, the patient has a tumor with aggressive histologies and worse prognosis. In such cases, we offer intensive treatment because we don’t have a consensus about the best management of this condition. In addition, only a few cases have been reported due to the rarity of collision tumors of cervix.

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