Objectives To evaluate the correlation between sarcopenia and operative/peri-operative outcomes in patients receiving primary debulking surgery (PDS) for newly-diagnosed advanced epithelial ovarian cancer (AEOC).
Methods All consecutive patiens affected by AEOC and submitted to PDS in our Institution were considered eligible. Total skeletal muscle surface (SKS) area was used as expression of sarcopenia and measured on axial computed tomography at the level of the third lumbar vertebra. Cox-regression and Kaplan-Meier analysis were used to analyse the relationship between sarcopenia and residual tumor. The effect of sarcopenia on the development of major surgical complications was studied with logistic regression.
Results From October 2018 and March 2019 121 patients were enrolled. Median values of SKS area were significantly lower in patients with RT> vs. =0. After multivariable analysis, sarcopenia resulted as an independent predictor of residual disease.
Conclusions Sarcopenia is an independent predictor of residual disease and peri-operative complications at the time of upfront cytoreduction for AEOC.
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