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Genetics and Epidemiology
IGCS19-0671
235 ABO, RH, KELL AND MN systems within uterine cancer
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  1. I Nakashidze1,
  2. N Kotrikadze2,
  3. M Nagervadze1,
  4. L Ramishvili2,
  5. M Alibegashvili2,
  6. N Petrovic3,
  7. N Kedelidze1,
  8. S Garakanidze1,
  9. B Sepiashvilli2,
  10. K Dolidze1,
  11. R Khukhunaishvili1,
  12. M Koridze1,
  13. D Baratashvili1 and
  14. S Ahmad4
  1. 1Batumi Shota Rustaveli State University, Department of Biology, Batumi, Georgia
  2. 2Ivane Javakhishvili Tbilisi State University, Department of Biology, Tbilisi, Georgia
  3. 3Vinca Institute of Nuclear Sciences University of Belgrade, Department for Radiobiology and Molecular Genetics, Belgrade, Serbia
  4. 4Florida Hospital Cancer Institute, Department of Gynecologic Oncology, Batumi, USA

Abstract

Objectives The blood group antigens are found in several human cell types. There is a variable expression of histo-blood groups antigens within normal endometrium, which are also involved in hormonal regulation of glycosyltransferase activity. We aimed to investigate ABO, RH-hR, Kel and MN systems in women with Uterine cancer (UCa) in Adjara (Georgia) population.

Methods Internationally recognized immunoserology methods were used to reveal the erythrocyte group antigens. The obtained results were statistically processed by using appropriate formulas.

Results From ABO system alleles, r and q alleles frequencies were higher within the patients with UCa compared with control group of patients. From Rh-Hr system, the distribution frequencies of D, c and e alleles, Cc, Ee and EE genotypes, cDe, cDE haplotypes are increased in UCa. From Kell q(k) and p (K) alleles, p(k) allele tends towards to UCa in the tumor. Notably, MN system p (M) and q(N) alleles, revealed q(N) allele increased frequency in UCa compared to control group.

Conclusions Based on our study, ABO, RH-hR, Kell and MN systems antigens may be may be useful for UCa predisposition and development.

https://doi.org/10.1136/ijgc-2019-IGCS.235

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