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Impact of transversus abdominis plane blocks versus non-steroidal anti-inflammatory on post-operative opioid use in ERAS ovarian cancer surgery
  1. Steven Peter Bisch1,
  2. Joni Kooy1,
  3. Sarah Glaze1,
  4. Anna Cameron1,
  5. Pamela Chu1,
  6. Prafull Ghatage1,
  7. Jill Nation1,
  8. Gregg Nelson1 and
  9. Garrett M Fitzmaurice2
  1. 1 Gynecologic Oncology, Tom Baker Cancer Centre, Calgary, Alberta, Canada
  2. 2 Laboratory for Psychiatric Biostatistics, McLean Hospital, Belmont, Massachusetts, USA
  1. Correspondence to Dr Steven Peter Bisch, Gynecologic Oncology, Tom Baker Cancer Centre, Calgary, AB T2N 4N2, Canada; steven.bisch{at}


Background Treatment of ovarian cancer often requires extensive surgical resection. The transversus abdominis plane (TAP) block has been utilized in benign gynecologic surgery to decrease post-operative pain and opioid use. We hypothesized that TAP blocks would decrease total opioid use in the first 24 hours and decrease length of stay following staging and cytoreductive surgery for ovarian cancer compared with either no local anesthetic or local wound infiltration alone.

Methods All patients undergoing surgery for ovarian cancer from November 2016 to June 2017 were included in this retrospective cohort study. Median opioid use at 24, 48, and 72 hours post-operatively, as well as length of stay, were assessed. Multivariate median regression analysis was performed to adjust for potential confounders: post-operative non-steroidal anti-inflammatory drug (NSAID) usage, pre-operative opioid consumption, and extent of cytoreductive surgery. Length of stay was compared using Cox regression analysis.

Results One-hundred-and-twenty patients were included in the analysis. Eighty-two patients had a TAP block, while 38 did not. After adjusting for potential confounders there was no difference in median 24 hours opioid consumption (p=0.29) or length of stay (HR 0.95, p=0.78) between patients receiving TAP block compared with those without. After adjusting for potential confounders, patients receiving scheduled NSAIDs had a 2.6-fold greater likelihood of being discharged (p<0.0005) and a significant reduction in median opioid use at 24 hours (23.5 vs 14.5 mg) (p=0.017) compared with those patients without NSAIDs.

Discussion Post-operative administration of NSAIDs, but not TAP block, was associated with a decrease in post-operative opioid use and length of stay following surgery for ovarian cancer. Further investigation into alternative regional anesthetics for Enhanced Recovery after Surgery (ERAS) protocols is warranted.

  • Enhanced recovery after surgery
  • transversus abdominis plane block
  • regional anesthesia
  • post-operative opioid use
  • ovarian cancer surgery
  • non-steroidal anti-inflammatory drugs
  • multimodal analgesia

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  • Contributors Statistical analysis: SB, GMF. SB, JK, SG, AC, PC, PG, JN, GN, and GMF were involved in all other aspects of the manuscript design and each contributed to writing and editing the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests GN is the Secretary for the ERAS Society.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.