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Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL Trial
  1. Benedetta Guani1,
  2. Maxence Dorez2,
  3. Laurent Magaud3,
  4. Annie Buenerd4,
  5. Fabrice Lecuru5 and
  6. Patrice Mathevet1,6
  1. 1 CHUV, Centre hospitalier universitaire vaudois, Lausanne, Switzerland
  2. 2 CHU de l'Archet 2, Nice, France
  3. 3 Public Health Department, Hospices Civils de Lyon, Lyon, France
  4. 4 Service d'anatomopathologie, Hôpital Femme Mère Enfant, Bron, France
  5. 5 Hôpital Européen George Pompidou, Paris, France
  6. 6 UNIL, Université de Lausanne, Lausanne, Switzerland
  1. Correspondence to Patrice Mathevet, CHUV, Centre hospitalier universitaire vaudois, Lausanne 1011, Switzerland; patrice.mathevet{at}chuv.ch

Abstract

Objectives The aim of this study was to evaluate the impact of micrometastasis and isolated tumor cells on disease recurrence in patients with early-stage cervical cancer.

Methods We included patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA1 with lymphvascular space invasion, stage IA2, and IB1 who participated in the SENTICOL1 trial. A centralized histologic analysis with re-reading and ultrastaging was performed 3 months after surgery and treatment was not impacted by findings from our study. Patients were followed for 3 years and outcomes were compared according to prognostic factors.

Results A total of 139 patients were included and 13 recurrences were found. There were two recurrences in patients with positive sentinel lymph node (SLN) (one macrometastases and one micrometastases) and 11 recurrences in patients with negative lymph nodes (sentinel or non-sentinel). Among patients with positive SLN for micrometastases there was only one recurrence. No patient with isolated tumor cells on their lymph nodes experienced a recurrence. There was a significant decrease in disease-free survival in patients aged >50 years (p = 0.01).

Conclusion Evidence of micrometastasis or isolated tumor cells in the SLN of untreated patients with early cervical cancer in the SENTICOL1 trial did not impact progression-free survival.

  • cervical cancer
  • sentinel lymph node
  • micrometastasis
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Footnotes

  • Correction notice This paper has been amended since it was first published online. This new version has undergone a medical edit, the funding statement has been updated and the title has been changed.

  • Funding Part of this study (ultrastaging of non sentinel pelvic lymh-nodes) was funded by a grant from the French National Cancer Institute to P. Mathevet: INCA-PHRC 2003.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned, externally peer reviewed.

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