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Original Article
Clinical application of the sentinel lymph node technique in early ovarian cancer: a pilot study
  1. V Lago1,
  2. P Bello2,
  3. B Montero3,
  4. L Matute1,
  5. P Padilla-Iserte1,
  6. S Lopez3,
  7. M Agudelo2 and
  8. S Domingo1
  1. 1 Department of Gynecologic Oncology, University Hospital La Fe, València, Spain
  2. 2 Department of Nuclear Medicine, University Hospital La Fe, València, Spain
  3. 3 Department of Pathology, University Hospital La Fe, València, Spain
  1. Correspondence to V Lago, Department of Gynecologic Oncology, University Hospital La Fe, Valencia 46026, Spain; victor.lago.leal{at}hotmail.com

Abstract

Introduction There is limited evidence favoring the use of the sentinel lymph node technique in ovarian cancer, and no standardized approach has been studied. The objective of the present pilot study is to determine the feasibility of the sentinel lymph node technique by applying a clinical algorithm.

Methods Patients with confirmed ovarian cancer were included. 99mTc and indocyanine green were injected into the ovarian and infundubulo-pelvic ligament stump. A gamma probe and near-infrared fluorescence imaging were used for sentinel lymph node detection.

Results The sentinel lymph node technique was performed in ten patients with a detection rate in the pelvic and/or para-aortic region of 100%. The tracer distribution rates of sentinel lymph nodes in the pelvic and para-aortic regions were 87.5% and 70%, respectively.

Conclusion The detection of sentinel lymph nodes in early-stage ovarian cancer appears to be achievable. Based on these results, a clinical trial entitled SENTOV (SENtinel lymph node Technique in OVarian cancer) will be performed.

  • ovarian cancer
  • early stage
  • sentinel lymph node
  • staging

https://doi.org/10.1136/ijgc-2018-000049

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    Footnotes

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Ethics approval Obtained.

    • Provenance and peer review Not commissioned, externally peer reviewed.