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A low albumin to globulin ratio with a high serum globulin level is a prognostic marker for poor survival in cervical cancer patients treated with radiation based therapy
  1. Yasunori Yoshino1,
  2. Ayumi Taguchi1,
  3. Takuya Shimizuguchi2,
  4. Yujiro Nakajima2,3,
  5. Maki Takao1,
  6. Tomoko Kashiyama1,
  7. Akiko Furusawa1,
  8. Nao Kino1 and
  9. Toshiharu Yasugi1
  1. 1 Department of Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  2. 2 Department of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  3. 3 Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
  1. Correspondence to Ayumi Taguchi, Ayumi Taguchi, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo 113-8677, Japan; aytaguchi-tky{at}umin.ac.jp

Abstract

Objective We investigated whether the pretreatment albumin to globulin ratio, serum albumin level, and serum globulin level can be used to predict survival among cervical cancer patients treated with radiation based therapy and assessed globulin fractions.

Methods We retrospectively enrolled 128 patients with cervical cancer treated with radiation based therapy at our institution between 2010 and 2015. The associations of the pretreatment albumin to globulin ratio, and serum albumin and globulin levels with overall survival were assessed. Additionally, the associations of the globulin fractions with the serum globulin levels and overall survival were evaluated.

Results Median follow-up duration was 30 months (IQR 16–44 months). A low albumin to globulin ratio (< 1.53) was found to be an independent prognostic factor for overall survival (HR= 3.07; 95% CI, 1.03 to 13.3; P=0.044). On evaluating serum globulin and albumin separately, a high serum globulin level was significantly associated with overall survival (cut-off value 2.9 g/dL; HR=3.74; 95% CI 1.08 to 23.6; P=0.036) whereas a low serum albumin level was not associated with overall survival (cut-off value 3.6 g/dL; HR=1.77; 95% CI 0.57 to 4.54; P=0.29). Electrophoresis data of the serum proteins revealed that the γ-globulin fraction was most strongly correlated with the globulin levels (P<0.001). Furthermore, a high γ-globulin level (≥1.28 g/dL) was significantly associated with poor overall survival (log rank test, P=0.034).

Conclusions A pretreatment low albumin to globulin ratio, which might be attributable to a high serum globulin level, can be used to predict poor prognosis in cervical cancer patients treated with radiation based therapy.

  • albumin-to-globulin ratio
  • cervical cancer
  • radiation therapy
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Footnotes

  • Contributors YY, AT designed the study, developed the methodology, collected the data, performed the analysis, and wrote the manuscript in consultation with TY. TS, YN worked out the technical details and wrote the manuscript. MT, TK, AF, NK, TY discussed the results and commented on the manuscript.

  • Funding This research was supported by the Clinical Research Fund of Tokyo Metropolitan Government and J-PRIDE from the Japan Agency for Medical Research and Development, AMED, under grant No 18fm0208013h0002.

  • Ethics approval This study has been approved by the research ethics committee of Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewd.

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