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Trends and Outcomes of Venous Thromboembolism in Hospitalized Patients With Ovarian Cancer: Results From Nationwide Inpatient Sample Database 2003 to 2011
  1. Varun Mittal, MD*,
  2. Shradha Ahuja, MD*,
  3. Sai Sharath Vejella, BDS, MPH*,
  4. Jessica M. Stempel, MD,
  5. Venkataraman Palabindala, MD*,
  6. Claudia M. Dourado, MD and
  7. John C. Leighton, MD
  1. *Division of Hospital Medicine, University of Mississippi Medical Center, Jackson, MS;
  2. Department of Internal Medicine, and
  3. Division of Hematology and Oncology, Einstein Health Care Network, Philadelphia, PA.
  1. Address correspondence and reprint requests to Varun Mittal, MD, Division of Hospital Medicine, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216. E-mail: vmittal{at}


Objective Venous thromboembolism (VTE) is a major cause of mortality and morbidity in hospitalized patients with malignancy. Nationwide Inpatient Sample database was analyzed to determine the trends in the rate of hospitalization and mortality from VTE in hospitalized ovarian cancer patients and assess its economic impact and resource utilization.

Method We queried the 2003 to 2011 Nationwide Inpatient Sample database from Healthcare Cost and Utilization project (Agency of Healthcare Research and Quality) to identify all adults (age ≥18 years) ovarian cancer. Patients hospitalized with VTE as one of the top 3 discharge diagnoses were also identified. Demographic characteristics and in-hospital outcomes of this population were compared with ovarian cancer patients without VTE. Binary logistic regression analysis was used to obtain adjusted odds ratios (ORs).

Results A total of 34,249 (3.5%) of a total of 981,386 hospitalized ovarian cancer patients had an accompanying diagnosis of VTE. Mean age of the study population was 64 years. After adjusting for potential confounders, compared with those without VTE, ovarian cancer patients with VTE had significantly higher inpatient mortality (6.2% vs 4.3%; OR, 1.12 [confidence interval (CI), 1.06–1.17]; P < .001), longer length of stay (5 vs 4 days; OR, 1.40 [CI, 1.36–1.43]; P < .001), higher average cost of hospitalization (US $26,000 vs US $22,000; OR, 1.10 [CI, 1.07–1.13]; P < .001), and greater disability at discharge (OR, 1.34 [CI, 1.31–1.38]; P < .001). Although the annual number of VTE admissions in ovarian cancer patients increased, in-hospital mortality declined from 10.9% in 2003 to 5.3% in 2011.

Conclusions Venous thromboembolism in hospitalized patients with ovarian cancer is associated with higher inpatient mortality, length of stay, higher cost of hospitalization, and disability at discharge. The hospitalization rate has increased, but the inpatient mortality rate has declined over study period.

  • Ovarian cancer
  • Venous thromboembolism
  • National inpatient sample database
  • Inpatient mortality
  • Outcome analysis

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  • The authors declare no conflicts of interest to declare.