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The Influence of Chemotherapy-Induced Peripheral Neuropathy on Quality of Life of Gynecologic Cancer Survivors
  1. Hirofumi Matsuoka, MD,
  2. Keiichiro Nakamura, MD, PhD,
  3. Yuko Matsubara, MD,
  4. Naoyuki Ida, MD,
  5. Masayuki Saijo, MD,
  6. Chikako Ogawa, MD, PhD and
  7. Hisashi Masuyama, MD, PhD
  1. Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  1. Address correspondence and reprint requests to Keiichiro Nakamura, MD, PhD, Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-tyo, Kita-ku, Okayama 700–8558, Japan. E-mail: k-nakamu{at}cc.okayama-u.ac.jp.

Abstract

Objective The aim of this observational study was to investigate correlations between long-term chemotherapy-induced peripheral neurotoxicity (CIPN) and quality of life (physical well-being, social well-being, emotional well-being, and functional well-being [FWB]) among survivors of gynecologic cancer (GC).

Methods We aimed to assess the correlation of quality of life and long-term CIPN with the temporal change in recurrence-free GC survival. Questionnaire responses and clinical data of 259 GC survivors were collected and assessed according to treatment received. The χ2 test was used to determine the significance of correlations.

Results Of 165 evaluable patients treated by chemotherapy, 36 patients (21.8%) developed CIPN of Common Toxicity Criteria for Adverse Events grade 1 or higher during the study. Chemotherapy-induced peripheral neurotoxicity had significantly improved over time in the domain of FWB at 61 months or more after the end of chemotherapy (posttreatment 4) among GC survivors (P = 0.003). Furthermore, CIPN treated by more than 6 courses of the paclitaxel and carboplatin regimen among GC survivors showed significant improvement over time in the emotional well-being domain at 25 to 60 months and 61 months or more after the end of chemotherapy (posttreatments 3 and 4) (P = 0.037 and P = 0.023) and in FWB at posttreatment 4 (P < 0.001).

Conclusions Emotional and functional domains of CIPN improved over time among GC survivors treated by more than 6 courses of the paclitaxel and carboplatin regimen. Based on these results, further research is required to identify additional preventative or curative approaches.

  • Gynecologic cancer survivors
  • Chemotherapy-induced peripheral neurotoxicity
  • Quality of life
  • Functional assessment of cancer therapy-general

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Footnotes

  • The authors declare no conflicts of interest.

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