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Ovarian Cancer Prevention, Screening, and Early Detection: Report From the 11th Biennial Ovarian Cancer Research Symposium
  1. Jeremy Chien, PhD* and
  2. Elizabeth M. Poole, PhD
  1. *University of Kansas Medical Center, Kansas City, KS; and
  2. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  1. Address correspondence and reprint requests to Elizabeth M. Poole, PhD, Biostatistics, Sanofi Genzyme, 500 Kendall St, Cambridge, MA 02142. E-mail: elizabeth.poole@sanofi.com.

Abstract

Objective The aim of this study is to provide a summary report on recent research advances in ovarian cancer prevention, screening, and early detection that were presented at the 11th Biennial Ovarian Cancer Research Symposium in Seattle, Wash.

Methods At the symposium, researchers from around the world participated in the poster, invited oral presentation and keynote presentation, and discussed the latest advances in the areas of cancer prevention, screening, and early detection.

Results In the Scientific Session for Prevention, Screening, and Early Detection, Usha Menon, PhD (University of College London), presented exploratory studies from the ongoing UK Collaborative Trial of Ovarian Cancer Screening trial. Karen Lu, MD, presented her studies on BRCA testing and salpingectomies as prevention strategies. Eight speakers were selected from the abstracts for short oral presentations, and the topic ranges from Ovarian Cancer Early Detection Program by Saul Rivkin, MD, to the ultra-deep sequencing of somatic mutations in TP53 in normal and cancer patients by Rosana Risques, PhD. Fourteen additional poster presentations, ranging from the potential role of cancer stem cells in recurrence to retrotransposons in ovarian cancer development, round up the session.

Conclusions Although progress is being made in the areas of prevention, screening, and early detection, these advances have not yet translated into tangible clinical benefits for patients with ovarian cancer. A wide array of research topics presented in the session provides a glimmer of hope that better understanding of genetic risk factors, refining screening strategies, and developing new methods for early detection will eventually lead to improved outcome for patients with ovarian cancer.

  • Ovarian cancer
  • Meeting report
  • Prevention
  • Screening
  • Early detection

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Footnotes

  • J.C. is supported by the University of Kansas Endowment Association, the University of Kansas Cancer Center Support Grant (P30-CA168524), the American Cancer Society Research Scholar (125618-RSG-14-067-01-TBE), and the Department of Defense Ovarian Cancer Research Program under award number (W81XWH-10-1-0386). E.M.P. is supported by the Department of Defense Ovarian Cancer Research Program (W81XWH-13-1-0493), the Rivkin Center's Skacel Family Scholar Award, and the National Cancer Institute (P01 CA87969).

  • Views and opinions of and endorsements by the author(s) do not reflect those of the US Army or the Department of Defense.

  • The authors declare no conflicts of interest.

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