Article Text

Download PDFPDF
Difference in Diffusion-Weighted Magnetic Resonance Imaging and Diffusion Tensor Imaging Parameters Between Endometrioid Endometrial Adenocarcinoma and Uterine Serous Adenocarcinoma: A Retrospective Study
  1. Shifeng Tian, MS*,
  2. Ailian Liu, MD*,
  3. Wen Zhu, MS,
  4. Ye Li, MS*,
  5. Lihua Chen, MS*,
  6. Anliang Chen, MS*,
  7. Jiageng Shen, BS*,
  8. Qingwei Song, MS* and
  9. Qiang Wei, MS*
  1. *Departments of Radiology and
  2. Departments of Pathology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
  1. Address correspondence and reprint requests to Ailian Liu, MD, Department of Radiology, the First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Xigang District, Dalian 116011, China. E-mail: liuailianl@163.com.

Abstract

Objective This study aimed to elucidate the difference in diffusion-weighted magnetic resonance imaging (DWI) and diffusion tensor imaging (DTI) parameters between endometrioid endometrial adenocarcinoma (EEA) and uterine serous adenocarcinoma (SA).

Methods Data of patients with pathologically confirmed EEA or SA who underwent DWI and DTI scanning between May 2013 and July 2016 were retrospectively analyzed. Apparent diffusion coefficient (ADC) value from DWI and ADC from DTI (ADCT) map and fractional anisotropy (FA) values from DTI were analyzed and compared statistically. The correlation between ADC and ADCT was analyzed by Pearson correlation analysis. Apparent diffusion coefficient, ADCT, and FA between the 2 groups were compared using independent t test. The effect of ADC, ADCT, and FA in distinguishing EEA and SA was evaluated by receiver operator characteristic curve.

Result Thirty-three patients were enrolled into the study, including 13 cases of SA and 20 cases of EEA. Pearson correlation analysis suggested that the value of ADC was highly related with ADCT in both the SA group (r = 0.812, P = 0.001) and the EEA group (r = 0.858, P < 0.001). The value of ADC and ADCT in the SA group was significantly lower than that in the EEA group; FA was significantly higher than that in the EEA group. Receiver operator characteristic curve analysis showed that ADC and ADCT have high sensitivity and specificity; FA has low sensitivity and high specificity.

Conclusions We suggest that both DWI and DTI could be used in distinguishing EEA from SA. Apparent diffusion coefficient and ADCT possess potential diagnostic value with high sensitivity and specificity.

  • Apparent diffusion coefficient
  • Endometrial cancer
  • Fractional anisotropy
  • Uterine serous adenocarcinoma

Statistics from Altmetric.com

Footnotes

  • The authors declare no conflicts of interest.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.