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Title Prognosis Significance of ZEB2 and TGF-β1 as well as Other Clinical Characteristics in Epithelial Ovarian Cancer
  1. Zhen Yan, MM*,
  2. Xiaoyu Tian, MD*,
  3. Ruifang Wang, MM*,
  4. Xiaolin Cheng, MM*,
  5. Jianqiang Mi, MM,
  6. Lili Xiong, MM*,
  7. Ying Wang, MM*,
  8. Jie Deng, MM* and
  9. Mengmeng Jia, MM*
  1. * Departments of Obstetrics and Gynecology, and
  2. Pathology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
  1. Address correspondence and reprint requests to Xiaoyu Tian, MD, Department of Obstetrics and Gynecology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Jianxi District, Jinghua Rd No. 24, Luoyang, Henan, China, 471003. E-mail: tianxiaoy1210{at}163.com.

Abstract

Objective This study aimed to evaluate the prognosis significance of zinc-finger E-box binding homeobox 2 (ZEB2) and transforming growth factor β1 (TGF-β1) as well as other clinical characteristics in epithelial ovarian cancer (EOC).

Methods This retrospective study examined the expressions of ZEB2 and TGF-β1 in 64 EOC specimens, 36 benign ovarian tumor specimens, and 28 normal ovarian specimens by immunohistochemistry. The correlation of the expressions of ZEB2 and TGF-β1 was analyzed by the Spearman rank correlation analysis. The Kaplan-Meier method was used to construct crude survival curves, and the prognostic roles of ZEB2 and TGF-β1 as well as clinical characteristics were evaluated by Cox proportional hazards regression analysis.

Results The positive expression rates of ZEB2 and TGF-β1 were increased in EOC specimens compared with benign ovarian tumor and normal ovary specimens (P < 0.05), and ZEB2 expression was positively correlated with TGF-β1 expression (r = 0.538, P = 0.000). In addition, the overall survival rate of EOC patients was associated with the expressions of ZEB2 and TGF-β1, age, differentiated grade, International Federation of Gynecology and Obstetrics (FIGO) stage, preoperative serum CA125 level, postoperative start time of chemotherapy, and treatment course (all P < 0.05). Multivariate Cox regression demonstrated that FIGO stage (P = 0.033), TGF-β1 expression (P = 0.043), postoperative start time of chemotherapy (P = 0.009), and treatment course (P = 0.000) were prognostic factors for EOC.

Conclusions ZEB2 and TGF-β1 may promote EOC progression, and FIGO stage, TGF-β1 expression, postoperative start time of chemotherapy, and treatment course may be associated with the prognosis of EOC.

  • Zinc-finger E-box binding homeobox 2
  • Transforming growth factor β1
  • Prognostic factors
  • Epithelial ovarian cancer
  • ZEB2 - zinc-finger E-box binding homeobox 2
  • TGF-β1 - transforming growth factor β1
  • FIGO - International Federation of Gynecology and Obstetrics
  • EMT - epithelial mesenchymal transition

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Footnotes

  • The authors declare no conflicts of interest.

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