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Cervical Cancer
Nomogram Predicting Overall Survival in Operable Cervical Cancer Patients
  1. Ru-ru Zheng, MD*,
  2. Xiao-wan Huang, MD*,
  3. Wen-Yue Liu, MD†,
  4. Rong-rong Lin, MD*,
  5. Fei-yun Zheng, MD* and
  6. Feng Lin, MD*
  1. *The Departments of Gynecology and
  2. †The Departments of Endocrinology and Metabolism, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou, People's Republic of China.
  1. Address correspondence and reprint requests to Fei-yun Zheng, MD, or Feng Lin, MD, First Affiliated Hospital of Wenzhou Medical University, Shangcaicun Rd, Wenzhou, Zhejiang, China. E-mail: zfy983023@hotmail.com; 234898067@qq.com.

Abstract

Objective Nomograms are widely used as predictive tools to predict oncological outcomes intuitively and precisely. The aim of our study was to develop a nomogram for predicting overall survival (OS) of patients with early stage cervical cancer.

Methods In this retrospective study, the clinical, pathological, and hematological data and prognosis of 795 cervical cancer patients were investigated. We identified and incorporated independent significant prognostic factors for OS to develop a nomogram. The predictive accuracy and discriminative ability were measured by concordance index.

Results By univariable analysis and subsequent multivariable analysis, we identified body mass index, albumin, platelet, leukocyte, tumor differentiation, and the status of the pelvic lymph node (PLN) (all P < 0.05) as independent prognostic factors. The concordance index of the nomogram integrating these 6 variables was 0.74. The calibration curves for probability of 3- and 5-year OS also demonstrated ideal agreement between nomogram prediction and actual observation.

Conclusions We developed a novel nomogram that can provide prediction of OS for patients with early stage cervical cancer individually. Furthermore, studies are required to validate whether it can be applied to other cohorts.

  • Nomogram
  • Cervical cancer
  • Overall survival
  • C-index

http://dx.doi.org/10.1097/IGC.0000000000000987

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    Footnotes

    • RR.Z. and XW.H. contributed equally to this work.

    • This study was supported by the Zhejiang Provincial Education Program (Y201430483).

    • The authors declare no conflict of interest.